Recombinant mouse IL-21R protein | NKMAX ATGP4056 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant mouse IL-21R protein

catalog :

ATGP4056

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant mouse IL-21R protein

Domain :

20-237aa

Catalog number (SKU) :

ATGP4056

NCBI :

NP_068687.1

Description :

IL-21R (Interleukin 21 receptor), also known as NILR, belongs to the type I cytokine receptor family and Type 4 subfamily. This receptor is Heterodimer with the common gamma subunit and transduces the growth promoting signal of IL21. It is important for the proliferation and differentiation of T cells, B cells, and NK cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. B cell IL‑21 R engagement induces Blimp-1, and is important for memory responses. It engagement on mouse NK cells enhances their cytotoxic activity and IFN-gamma production. It is selectively expressed in lymphoid tissues and most highly expressed in thymus and spleen and IL21 impacts some cell types, including CD8+ memory T cells, NK cells, and subsets of CD4 memory T cells. It is also necessary for sufficient numbers of regulatory T cells to combat chronic inflammation. Recombinant mouse IL21R, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-21 receptor, IL-21 receptor, IL-21R, Il21r, Lymphocyte receptor beta, LR-beta, Novel interleukin receptor, Novel cytokine receptor 8, NR8, Novel interleukin receptor, CD360, CD360 antigen, NILR, Nilr, Uscroproteinmagleukin-21 receptor, 2

Concentration :

1mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Parrish-Novak, et al. (2000) Nature 408:57-63;; Mol Cell Biol. (2005) Nov; 25(22): 9741–9752.;; De Totero D, et al. (2006) Blood. 107(9): 3708-3715.;; Kasaian, M.T. et al. (2002) Immunity 16:559-569.;;

Purity :

> 95% by SDS - PAGE

Bioactivity Comment Only :

Measured by its ability to inhibit IFN-g secretion using NK-92 human natural killer cells. The ED50 range ≤ 4 ug/ml with mouse IL-2(CAT# ATGP4049).

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Mouse

Gene Category :

Immunology, Hormones & Cytokines

Molecular Weight :

52kDa (457aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Mouse IL-21R inhibits the IFN-g secretion of the NK-92 human natural killer cells in the presence of mouse IL-21(CAT# ATGP4049). The ED50 range ≤ 4 ug/ml.

Amino Acid Sequence :

CLDLTCYTDY LWTITCVLET RSPNPSILSL TWQDEYEELQ DQETFCSLHR SGHNTTHIWY TCHMRLSQFL SDEVFIVNVT DQSGNNSQEC GSFVLAESIK PAPPLNVTVA FSGRYDISWD SAYDEPSNYV LRGKLQYELQ YRNLRDPYAV RPVTKLISVD SRNVSLLPEE FHKDSSYQLQ VRAAPQPGTS FRGTWSEWSD PVIFQTQAGE PEAGWDPH

Tag :

hIgG-His-Tag

Expression System :

HEK293

Predicted nterm :

cys 20

Product Type Name :

Recombinant Protein

UniProt No. :

Q9JHX3

Internal Search Terms :

ATGP4056-10ug,ATGP4056-20ug,ATGP4056-50ug,ATGP4056-100ug,ATGP4056-250ug,ATGP4056-500ug,ATGP4056-1mg,ATGP4056-10,ATGP4056-20,ATGP4056-50,ATGP4056-100,ATGP4056-250,ATGP4056-500,ATGP4056-1

more info or order :

NKMAX product webpage