Recombinant human OX40/TNFRSF4 protein | NKMAX ATGP4045 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human OX40/TNFRSF4 protein

catalog :

ATGP4045

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human OX40/TNFRSF4 protein

Domain :

29-214aa

Catalog number (SKU) :

ATGP4045

NCBI :

NP_003318.1

Description :

TNFRSF4, also known as tumor necrosis factor receptor superfamily member 4, is a T cell co-stimulatory molecule in the TNF receptor superfamily. This protein coordinates with other co-stimulatory substances (CD28, CD40, CD30, CD27 and 4-1BB) to control the activation of the immune response. It plays an important role in antigen-specific T cell expansion and survival. It is up-regulated on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. This protein also regulates cytokine production from T cells, antigen presenting cells, natural killer cells and natural killer cells and regulate cytokine receptor signaling. Recombinant human TNFRSF4, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Tumor necrosis factor receptor superfamily member 4, TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Hori, T., et al. (2006) Int. J. Hematol. 83:17-22.;; Moran, A.E., et al. (2013) Curr. Opin. Immunol. 25:230-237.;;

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with mouse OX40 Ligand/TNFSF4 (CAT# ATGP4022). The ED50 range ≤ 0.15 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

46.9KDa (425aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Mouse OX40 Ligand/TNFSF4 (CAT# ATGP4022) is coated at 1 ug/ml (100 ul/well) can bind Human TNFRSF4. The ED50 range ≤ 0.15 ug/ml.

Amino Acid Sequence :

LHCVGDTYPS NDRCCHECRP GNGMVSRCSR SQNTVCRPCG PGFYNDVVSS KPCKPCTWCN LRSGSERKQL CTATQDTVCR CRAGTQPLDS YKPGVDCAPC PPGHFSPGDN QACKPWTNCT LAGKHTLQPA SNSSDAICED RDPPATQPQE TQGPPARPIT VQPTEAWPRT SQGPSTRPVE VPGGRA

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Leu29

Product Type Name :

Recombinant Protein

UniProt No. :

P43489

Internal Search Terms :

ATGP3686, ATGP4045-10ug,ATGP4045-20ug,ATGP4045-50ug,ATGP4045-100ug,ATGP4045-250ug,ATGP4045-500ug,ATGP4045-1mg,ATGP4045-10,ATGP4045-20,ATGP4045-50,ATGP4045-100,ATGP4045-250,ATGP4045-500,ATGP4045-1

more info or order :

NKMAX product webpage