Recombinant canine IL-8/CXCL8 protein | NKMAX ATGP4043 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant canine IL-8/CXCL8 protein

catalog :

ATGP4043

quantity :

10 ug

price :

150 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant canine IL-8/CXCL8 protein

Domain :

28-101aa

Catalog number (SKU) :

ATGP4043

NCBI :

NP_001003200.1

Description :

IL-8/CXCL8, also known as Interleukin-8, GCP-1, and NAP-1 is a member of the CXC family of chemokines family which is widely expressed proinflammatory. IL-8 is a potent neutrophil chemotactic factor. It attracts neutrophils, basophils, and T-cells, but not monocytes. This protein has two primary functions. It induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. IL-8 also stimulates phagocytosis once they have arrived. IL-8 is also known to be a potent promoter of angiogenesis. In target cells, IL-8 induces a series of physiological responses required for migration and phagocytosis, such as increases in intracellular Ca2+, exocytosis, and the respiratory burst. Among the eceptors on the surface membrane capable of binding IL-8, the most frequently studied receptors are CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). Recombinant canine IL-8/CXCL8, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-8, C-X-C motif chemokine 8, Chemokine (C-X-C motif) ligand 8

Concentration :

0.25mg/ml (determined by BCA assay)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Lazennec, G. and A. Richmond (2010) Trends Mol. Med. 16:133-144.;; Munoz, L.M. et al. (2009) J. Immunol. 183:7337-7346.;; Bergin, D.A. et al. (2010) J. Clin. Invest. 120:4236-4250.;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Canine

Gene Category :

Hormones & Cytokines, Angiogenesis, Cardiovascular

Molecular Weight :

9.4 kDa (80aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

VSSELRCQCI KTHSTPFHPK YIKELRVIDS GPHCENSEII VKLFNGNEVC LDPKEKWVQK VVQIFLKKAE KQDP

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Val 28

Product Type Name :

Recombinant Protein

UniProt No. :

P41324

Internal Search Terms :

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more info or order :

NKMAX product webpage