Recombinant human IL-17RB protein | NKMAX ATGP4039 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-17RB protein

catalog :

ATGP4039

quantity :

10 ug

price :

137 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-17RB protein

Domain :

18-292aa

Catalog number (SKU) :

ATGP4039

NCBI :

NP_061195.2

Description :

IL-17RB, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17A or IL17C. It has been shown to mediate the activation of NFkappaB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. Recombinant human IL-17RB, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-17 receptor B, CRL4, EVI27, IL17BR, IL17RH1, IL-17 receptor B, IL-17RB, Cytokine receptor-like 4, IL-17 receptor homolog 1, Interleukin-17B receptor

Concentration :

0.25mg/ml (determined by Bradford assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Ma XJ,. et al. (2006) J Clin Oncol. 24:4611-4619.;; Schwandner R,. et al. (2000) J. Exp. Med. 191:1233–1240.

Purity :

> 85% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human IL25 (CAT# ATGP4018). The ED50 range ≤ 2 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

57.3 kDa (514aa) Reducing conditions

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human IL25 (CAT# ATGP4018) is coated at 2 ug/ml (100 ul/well) can bind Human IL17RB. The ED50 range ≤ 2 ug/ml.

Amino Acid Sequence :

REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMN VSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIG AHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRY MALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVP FPLDNNKSKP GGWLP

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Arg18

Product Type Name :

Recombinant Protein

UniProt No. :

Q9NRM6

Internal Search Terms :

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more info or order :

NKMAX product webpage