Recombinant human Thrombospondin 5/COMP protein | NKMAX ATGP4037 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Thrombospondin 5/COMP protein

catalog :

ATGP4037

quantity :

10 ug

price :

124 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Thrombospondin 5/COMP protein

Domain :

21-757aa

Catalog number (SKU) :

ATGP4037

NCBI :

NP_000086.2

Description :

COMP, also known as Thrombospondin-5, is a member of the thrombospondin(TSP) family. It is an extracellular matrix(ECM) protein primarily present in cartilage and is a secreted glycoprotein that is important for growth plate organization and function. This protein is upregulated in rheumatoid osteoarthritis and arthritis, chronic pancreatitis, hepatocellular carcinomas and pancreatic carcinomas. It is a marker of cartilage turnover. It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling. It also plays a role in cell growth and development. Mutations in COMP can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas. Recombinant human COMP, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

cartilage oligomeric matrix protein, Thrombospondin-5, EDM1, EPD1, MED, PSACH, THBS5, TSP5, COMP, CTS2

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Wislowska M., et al, (2005) Clin. Rheumatol. 24:278-284. ;; Hou J., et al, (2000) Cell Calcium. 27:309-314.

Purity :

> 85% by SDS - PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Signal Transduction, Cytoskeleton

Molecular Weight :

82.4kDa (749aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

QGQSPL GSDLGPQMLR ELQETNAALQ DVRELLRQQV REITFLKNTV MECDACGMQQ SVRTGLPSVR PLLHCAPGFC FPGVACIQTE SGARCGPCPA GFTGNGSHCT DVNECNAHPC FPRVRCINTS PGFRCEACPP GYSGPTHQGV GLAFAKANKQ VCTDINECET GQHNCVPNSV CINTRGSFQC GPCQPGFVGD QASGCQRRAQ RFCPDGSPSE CHEHADCVLE RDGSRSCVCA VGWAGNGILC GRDTDLDGFP DEKLRCPERQ CRKDNCVTVP NSGQEDVDRD GIGDACDPDA DGDGVPNEKD NCPLVRNPDQ RNTDEDKWGD ACDNCRSQKN DDQKDTDQDG RGDACDDDID GDRIRNQADN CPRVPNSDQK DSDGDGIGDA CDNCPQKSNP DQADVDHDFV GDACDSDQDQ DGDGHQDSRD NCPTVPNSAQ EDSDHDGQGD ACDDDDDNDG VPDSRDNCRL VPNPGQEDAD RDGVGDVCQD DFDADKVVDK IDVCPENAEV TLTDFRAFQT VVLDPEGDAQ IDPNWVVLNQ GREIVQTMNS DPGLAVGYTA FNGVDFEGTF HVNTVTDDDY AGFIFGYQDS SSFYVVMWKQ MEQTYWQANP FRAVAEPGIQ LKAVKSSTGP GEQLRNALWH TGDTESQVRL LWKDPRNVGW KDKKSYRWFL QHRPQVGYIR VRFYEGPELV ADSNVVLDTT MRGGRLGVFC FSQENIIWAN LRYRCNDTIP EDYETHQLRQ A

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Asp

Product Type Name :

Recombinant Protein

UniProt No. :

P49747

Internal Search Terms :

ATGP4037-10ug,ATGP4037-20ug,ATGP4037-50ug,ATGP4037-100ug,ATGP4037-250ug,ATGP4037-500ug,ATGP4037-1mg, ATGP4037-10,ATGP4037-20,ATGP4037-50,ATGP4037-100,ATGP4037-250,ATGP4037-500,ATGP4037-1

more info or order :

NKMAX product webpage