Recombinant human PGLYRP1/PGRP-S protein | NKMAX ATGP4036 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human PGLYRP1/PGRP-S protein

catalog :

ATGP4036

quantity :

10 ug

price :

132 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human PGLYRP1/PGRP-S protein

Domain :

22-196aa

Catalog number (SKU) :

ATGP4036

NCBI :

NP_005082.1

Description :

PGLYRP1, also known as peptidoglycan recognition protein 1, is an innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. It acts as a pattern receptor that binds to murein peptidoglycans of gram-positive bacteria and provides bactericidal activity. PGLYRP1 forms an equimolar complex with HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. This protein also interacts with S100A4 and function as a chmoattractant which induces lymphocyte movement. Recombinant human PGLYRP1, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L, Peptidoglycan recognition protein 1, peptidoglycan recognition protein short

Concentration :

0.25mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles

General References :

Lang MF, et al, (2008) Neurosci Lett. 430:138-141.;; Sharma P., et al, (2012) Int J Biochem Mol Biol. 3:86-94.;; Sun Q., et al, (2014) World J Microbiol Biotechnol. 30:263-270.;;

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Peptidoglycan. The ED50 range ≤ 30 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Apoptosis

Molecular Weight :

20.5kDa (184aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Peptidoglycan is coated at 10 ug/ml (100 ul/well) can bind Human PGLYRP1. The ED50 range ≤ 30 ng/ml.

Amino Acid Sequence :

QETEDPA CCSPIVPRNE WKALASECAQ HLSLPLRYVV VSHTAGSSCN TPASCQQQAR NVQHYHMKTL GWCDVGYNFL IGEDGLVYEG RGWNFTGAHS GHLWNPMSIG ISFMGNYMDR VPTPQAIRAA QGLLACGVAQ GALRSNYVLK GHRDVQRTLS PGNQLYHLIQ NWPHYRSP

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Asp

Product Type Name :

Recombinant Protein

UniProt No. :

O75594

Internal Search Terms :

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more info or order :

NKMAX product webpage