Recombinant mouse Thrombospondin 4/THBS4 protein | NKMAX ATGP4035 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant mouse Thrombospondin 4/THBS4 protein

catalog :

ATGP4035

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant mouse Thrombospondin 4/THBS4 protein

Domain :

27-963aa

Catalog number (SKU) :

ATGP4035

NCBI :

NP_035712.1

Description :

Thrombospondin-4, also known as THBS4, is a member of the thrombospondin protein family. This family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Among them Thrombospondin-4 binds a variety of matrix proteins including Collagens I, II, III, V, Laminin‑1, Fibronectin, and Matrilin‑2. And it plays a role in cardiovascular physiology and neuronal development. It is up‑regulated in the spinal cord following peripheral nerve injury where it contributes to presynaptic hypersensitivity and hyperalgesia. It is also up‑regulated in muscle following denervation. It contributes to the development of inflammation and atherosclerosis by promoting macrophage and neutrophil adhesion to the vasculature. Recombinant mouse Thrombospondin-4, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

THBS4, Thrombospondin 4, TS, TSP, TSP4

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 0.1mM PMSF, 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Lawler, J. et al. (1995) J. Biol. Chem. 270:2809-2814.;; Narouz-Ott, L. et al. (2000) J. Biol. Chem. 275:37110-37117.;; Arber, S. and P. Caroni (1995) J. Cell Biol. 131:1083-1094.;;Muppala S. et al.(2015) Arteriosclerosis. 1975-1986.;;

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Mouse

Gene Category :

Angiogenesis, Cardiovascular, Adhesion & Movement

Molecular Weight :

104.3 kDa (943aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

QATPQVFDLL PSSSQRLNPS ALQPVLTDPT LHEVYLISTF KLQSKSSATI FGLYSSSDNS KYFEFTVMGR LNKAILRYLK NDGKIHLVVF NNLQLADGRR HRVLLRLSNL QRGDGSVELY LDCAQADSVR NLPRAFSGLT QNPESIELRT FQRKPQDFLE ELKLVVRGSL FQVASLQDCF LQQSEPLAAT STGDFNRQFL GQMTQLNQLL GEVKDLLRQQ VKETSFLRNT IAECQACGPL SFQSPTPNTL VPIAPPAPPT RPTRHCDSSP CFRGVRCTDT RDGFQCGPCP DGYTGNGITC SDVDECKYHP CYPGVRCVNL APGFRCDACP VGFTGPMVQG VGINFAKTNK QVCTDVDECQ NGACVLNSIC INTLGSYRCG PCKPGYTGDQ TRGCKTERSC RNPEQNPCSV HAQCIEERQG DVTCVCGVGW AGDGYVCGKD VDIDSYPDEE LPCSARNCKK DNCKYVPNSG QEDADRDGIG DACDEDADGD GILNEQDNCV LTHNIDQRNS DKDIFGDACD NCRMVLNNDQ KDTDGDGRGD ACDDDMDGDG IKNILDNCPR VPNRDQQDRD GDDVGDACDS CPDVSNPNQS DVDNDLVGDS CDTNQDSDGD GHQDSTDNCP TVINSSQLDT DKDGIGDECD DDDDNDGIPD LVPPGPDNCR LVPNPAQEDS NNDGVGDICE ADFDQDQVID HIDVCPENAE ITLTDFRAYQ TVVLDPEGDA QIDPNWVVLN QGMEIVQTMN SDPGLAVGYT AFNGVDFEGT FHVNTQTDDD YAGFIFGYQD SSSFYVVMWK QTEQTYWQAT PFRAVAEPGI QLKAVKSKTG PGEHLRNSLW HTGDTSDQVR LLWKDSRNVG WKDKVSYRWF LQHRPQVGYI RVRFYEGSEL VADSGVTIDT TMRGGRLGVF CFSQENIIWS NLKYRCNDTI PEDFQEFQTQ SFDRLDN

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Gln27

Product Type Name :

Recombinant Protein

UniProt No. :

Q9Z1T2

Internal Search Terms :

THBS 4, THBS4, THBS-4, Thrombospondin 4, Thrombospondin4, Thrombospondin-4, TS, TSP, TSP4, TSP-4, TSP 4, ATGP4035-10ug, ATGP4035-20ug, ATGP4035-50ug, ATGP4035-100ug, ATGP4035-250ug, ATGP4035-500ug, ATGP4035-1mg, ATGP4035-010, ATGP4035-020, ATGP4035-050, ATGP4035-100, ATGP4035-250, ATGP4035-500, ATGP4035-01M

more info or order :

NKMAX product webpage