Recombinant human L1CAM protein | NKMAX ATGP4032 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human L1CAM protein

catalog :

ATGP4032

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human L1CAM protein

Domain :

20-1115aa

Catalog number (SKU) :

ATGP4032

NCBI :

NP_001137435

Description :

L1CAM, also known as neural cell adhesion molecule L1 isoform 3, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. It is now recognized to play a key role in cell migration, adhesion, neurite outgrowth, myelination and neuronal differentiation Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate and promoted cell transformation and tumorigenicity. Recombinant human L1CAM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Neural cell adhesion molecule L1 isoform 3, L1CAM, CAML1, CD171, HSAS, HSAS1, MASA, MIC5, N-CAM-L1, N-CAML1, NCAM-L1, S10, SPG1

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Maness, P.F., et al. (2007) Nat. Neurosci. 10:19-26.;; Gavert, N., et al. (2008) Expert Opin Biol Ther. 8(11):1749-57.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by the ability of the immobilized protein to support the adhesion of Neuro-2a mouse neuroblastoma cells. When cells are added to human L1CAM coated plates 1 ug/ml. This effect is more to 30%.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Signal Transduction, Cytoskeleton, Adhesion & Movement

Molecular Weight :

123.6 kDa (1104aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

IQIPEELMEP PVITEQSPRR LVVFPTDDIS LKCEASGKPE VQFRWTRDGV HFKPKEELGV TVYQSPHSGS FTITGNNSNF AQRFQGIYRC FASNKLGTAM SHEIRLMAEG APKWPKETVK PVEVEEGESV VLPCNPPPSA EPLRIYWMNS KILHIKQDER VTMGQNGNLY FANVLTSDNH SDYICHAHFP GTRTIIQKEP IDLRVKATNS MIDRKPRLLF PTNSSSHLVA LQGQPLVLEC IAEGFPTPTI KWLRPSGPMP ADRVTYQNHN KTLQLLKVGE EDDGEYRCLA ENSLGSARHA YYVTVEAAPY WLHKPQSHLY GPGETARLDC QVQGRPQPEV TWRINGIPVE ELAKDQKYRI QRGALILSNV QPSDTMVTQC EARNRHGLLL ANAYIYVVQL PAKILTADNQ TYMAVQGSTA YLLCKAFGAP VPSVQWLDED GTTVLQDERF FPYANGTLGI RDLQANDTGR YFCLAANDQN NVTIMANLKV KDATQITQGP RSTIEKKGSR VTFTCQASFD PSLQPSITWR GDGRDLQELG DSDKYFIEDG RLVIHSLDYS DQGNYSCVAS TELDVVESRA QLLVVGSPGP VPRLVLSDLH LLTQSQVRVS WSPAEDHNAP IEKYDIEFED KEMAPEKWYS LGKVPGNQTS TTLKLSPYVH YTFRVTAINK YGPGEPSPVS ETVVTPEAAP EKNPVDVKGE GNETTNMVIT WKPLRWMDWN APQVQYRVQW RPQGTRGPWQ EQIVSDPFLV VSNTSTFVPY EIKVQAVNSQ GKGPEPQVTI GYSGEDYPQA IPELEGIEIL NSSAVLVKWR PVDLAQVKGH LRGYNVTYWR EGSQRKHSKR HIHKDHVVVP ANTTSVILSG LRPYSSYHLE VQAFNGRGSG PASEFTFSTP EGVPGHPEAL HLECQSNTSL LLRWQPPLSH NGVLTGYVLS YHPLDEGGKG QLSFNLRDPE LRTHNLTDLS PHLRYRFQLQ ATTKEGPGEA IVREGGTMAL SGISDFGNIS ATAGENYSVV SWVPKEGQCN FRFHILFKAL GEEKGGASLS PQYVSYNQSS YTQWDLQPDT DYEIHLFKER MFRHQMAVKT NGTGRVRLPP AGFATE

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ile20

Product Type Name :

Recombinant Protein

UniProt No. :

P32004

Internal Search Terms :

ATGP3618,ATGP4032-10ug,ATGP4032-20ug,ATGP4032-50ug,ATGP4032-100ug,ATGP4032-250ug,ATGP4032-500ug,ATGP4032-1mg,ATGP4032-10,ATGP4032-20,ATGP4032-50,ATGP4032-100,ATGP4032-250,ATGP4032-500,ATGP4032-1

more info or order :

NKMAX product webpage