Recombinant human SIRP gamma/CD172g protein | NKMAX ATGP4030 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human SIRP gamma/CD172g protein

catalog :

ATGP4030

quantity :

10 ug

price :

82 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human SIRP gamma/CD172g protein

Domain :

29-360aa

Catalog number (SKU) :

ATGP4030

NCBI :

NP_061026.2

Description :

SIRPG, also known as signal-regulatory protein gamma isoform 1, is a member of a closely related family of three cell surface receptors implicated in modulating immune/inflammatory responses. It is the only SIRP known to be expressed on T cells, CD56 bright NK cells and activated NK cells. Expression of SIRPG on T cells suggests a role as an accessory protein interacting with CD47‑expressing antigen presenting cells. Engagement of CD47 by SIRPG was shown to induce apoptosis on T-cell and monocyte cell lines. Recombinant human SIRPG, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Signal-regulatory protein gamma isoform 1, SIRPG, bA77C3.1, CD172g, SIRP-B2, SIRPB2, SIRPgamma

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Nettleship JE., et al. (2013) BMC Struct Biol. 13:13.;; Brooke G., et al. (2004) J Immunol. 173:2562-2570.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human CD47 (CAT# ATGP4015). The ED50 range ≤ 1 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology, Adhesion & Movement

Molecular Weight :

64 kDa (574aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human CD47 (CAT# ATGP4015) is coated at 1 ug/ml (100 ul/well) can bind Human SIRP gamma/CD172g. The ED range ≤ 1 ug/ml.

Amino Acid Sequence :

EEELQMI QPEKLLLVTV GKTATLHCTV TSLLPVGPVL WFRGVGPGRE LIYNQKEGHF PRVTTVSDLT KRNNMDFSIR ISSITPADVG TYYCVKFRKG SPENVEFKSG PGTEMALGAK PSAPVVLGPA ARTTPEHTVS FTCESHGFSP RDITLKWFKN GNELSDFQTN VDPTGQSVAY SIRSTARVVL DPWDVRSQVI CEVAHVTLQG DPLRGTANLS EAIRVPPTLE VTQQPMRVGN QVNVTCQVRK FYPQSLQLTW SENGNVCQRE TASTLTENKD GTYNWTSWFL VNISDQRDDV VLTCQVKHDG QLAVSKRLAL EVTVHQKDQS SDATP

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q9P1W8

Internal Search Terms :

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more info or order :

NKMAX product webpage