Recombinant mouse IL-5 Protein | NKMAX ATGP4029 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant mouse IL-5 Protein

catalog :

ATGP4029

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant mouse IL-5 Protein

Domain :

21-133aa

Catalog number (SKU) :

ATGP4029

NCBI :

NP_034688

Description :

IL5, also known as interleukin-5, is a member of the hematopoietin receptor superfamily and is comprised of a cytokine-specific alpha chain and the common beta chain that is shared among these cytokines for signaling. This interleukin produced by type-2 T helper cells and mast cells. It related hematopoietic cytokines that are important for allergic inflammation. It is a lineage-specific cytokine for eosinophilpoiesis and plays an important part in diseases associated with increased eosinophils, such as asthma. In humans, IL-5 primarily affects cells of the eosinophilic lineage, and promotes their differentiation, maturation, activation, migration and survival, while in mice IL-5 also enhances Ig class switching and release from B1 cells. IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release. Recombinant mouse IL-5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-5, B-cell growth factor II, BCGF-II, Cytotoxic T-lymphocyte inducer, Eosinophil differentiation factor, T-cell replacing factor, TRF, EDF

Concentration :

0.25mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Shen HH., et al, (2003) J. Immunol. 170 (6): 3296–3305.;; Sanderson CJ., et al, (1992) Blood. 79 (12): 3101–3109.

Purity :

> 90% by SDS - PAGE

Bioactivity Comment Only :

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 range ≤ 1 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Mouse

Gene Category :

Immunology

Molecular Weight :

13.9kDa (119aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Mouse IL-5 in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 range ≤ 1 ng/ml.

Amino Acid Sequence :

MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Met 21

Product Type Name :

Recombinant Protein

UniProt No. :

P04401

Internal Search Terms :

TRFB cell differentiation factor I, TRF, T-cell replacing factor, T cell replacing factor, Interleukin-5, Interleukin5, Interleukin 5, IL-5, IL5, IL 5, Eosinophil differentiation factor, EDF, Cytotoxic T-lymphocyte inducer, Cytotoxic T lymphocyte inducer, BCGF-II, BCGFII, BCGF II, B-cell growth factor II, B-cell differentiation factor I, B cell growth factor II, B cell differentiation factor I, ATGP4029-10ug, ATGP4029-20ug, ATGP4029-50ug, ATGP4029-100ug, ATGP4029-250ug, ATGP4029-500ug, ATGP4029-1mg, ATGP4029-010, ATGP4029-020, ATGP4029-050, ATGP4029-100, ATGP4029-250, ATGP4029-500, ATGP4029-01M

more info or order :

NKMAX product webpage