Recombinant human IL-19 protein | NKMAX ATGP4024 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-19 protein

catalog :

ATGP4024

quantity :

10 ug

price :

150 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-19 protein

Domain :

25-177aa

Catalog number (SKU) :

ATGP4024

NCBI :

NP_037503.2

Description :

IL-19, also known as Interleukin-19, is a member of the IL-10 family of related cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. This protein is an immunosuppressive cytokine that is responsible for both cell type-specific and system-specific down-regulation of inflammation, because it up-regulates IL-6 and TNF-α, and induces apoptosis through TNF-α. It binds a receptor complex consisting of the IL-20 receptor alpha (IL-20 R1) and the IL-20 receptor beta (IL-20 R2). This receptor complex is also shared by IL-20 and IL-24. IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. It may contribute to the pathogenesis of inflammatory bowel disease. Recombinant human IL-19, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-19, IL-19, Melanoma differentiation-associated protein-like protein, NG.1, ZMDA1, MDA1, IL-10C, IL19, Interleukin19, Macrophagleukin-19, IL-19, 2

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Gallagher, G. et al. (2000) Genes Immun. 1:442-450;; Gallagher, G. et al. (2004) Int. Immunopharmacol. 4:615-626.;; Pestka, S. et al. (2004) Annu. Rev. Immunol. 22:929-979.;; Dumoutier, L. et al. (2001) J. Immunol. 167:3545-3549.;; Parrish-Novak, J. et al. (2002) J. Biol. Chem. 277:47517-47523.;; Jordan, W.J. et al. (2005) Eur. J. Immunol. 35:1576-1582.;;

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology, Hormones & Cytokines

Molecular Weight :

19.1 kDa (164aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

LRRCL ISTDMHHIEE SFQEIKRAIQ AKDTFPNVTI LSTLETLQII KPLDVCCVTK NLLAFYVDRV FKDHQEPNPK ILRKISSIAN SFLYMQKTLR QCQEQRQCHC RQEATNATRV IHDNYDQLEV HAAAIKSLGE LDVFLAWINK NHEVMFSA

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Asp

Product Type Name :

Recombinant Protein

UniProt No. :

Q9UHD0

Internal Search Terms :

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more info or order :

NKMAX product webpage