Recombinant human ULBP-6/RAET1L Protein | NKMAX ATGP4023 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human ULBP-6/RAET1L Protein

catalog :

ATGP4023

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human ULBP-6/RAET1L Protein

Domain :

26-218aa

Catalog number (SKU) :

ATGP4023

NCBI :

NP_570970

Description :

RAET1L, also known as retinoic acid early transcript 1L, linked to the cell membrane by the GPI anchor. This protein functions as a stress-induced ligand for NKG2D receptor. Its expression is, for example, triggered in course of HCMV infection, but HCMV alters its function. HCMV-encoded UL16 glycoprotein retains RAET1L/ULBP6 inside the cells, preventing it from reaching the cell surface and being exposed to cells of the immune system. It had a more restricted expression proﬁle in cell lines and primary human tissues than other NKG2D ligands. RAET1L mRNA shows restricted expression in the trachea and some HPV positive cervical carcinoma and colorectal carcinoma cell lines. Recombinant human RAET1L, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

early transcript 1L, ULBP6, UL16-binding protein 6 ,RAET1L, retinoic acid early transcript 1L protein, retinoic acid early transcript 1L

Concentration :

1mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Eagle R.A., et al. (2009) Eur. J. Immunol. 39:3207.;; Kondo M., et al. (2010) Immunogenetics 62:441.

Purity :

> 95% by SDS - PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human NKG2D (CAT# ATGP3662).

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

22.9kDa (202aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human RAET1L/ULBP6 is coated at 10 ug/ml (100 ul/well) can bind Human NKG2D (CAT# ATGP3662) in a Functional ELISA assay.

Amino Acid Sequence :

RRDDPHS LCYDITVIPK FRPGPRWCAV QGQVDEKTFL HYDCGNKTVT PVSPLGKKLN VTMAWKAQNP VLREVVDILT EQLLDIQLEN YTPKEPLTLQ ARMSCEQKAE GHSSGSWQFS IDGQTFLLFD SEKRMWTTVH PGARKMKEKW ENDKDVAMSF HYISMGDCIG WLEDFLMGMD STLEPSAGAP LAMSSG

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q5VY80

Internal Search Terms :

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more info or order :

NKMAX product webpage