Recombinant human IL-17E/IL-25 protein | NKMAX ATGP4018 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-17E/IL-25 protein

catalog :

ATGP4018

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-17E/IL-25 protein

Domain :

33-177aa

Catalog number (SKU) :

ATGP4018

NCBI :

NP_073626.1

Description :

IL-25, also known as IL-17E, belongs to the IL-17 cytokine family. It support the Th2 immune response, and has been shown to induce the production of IL-4, IL-5 and IL-13. This is in contrast to other IL-17 family members which promote Th1- and Th17-biased inflammation. Because IL-25 promotes the development of a Th2 immune response, it acts to protect against several bowel infections caused by helminths. It is also referred to as the regulator of IL-9 production. IL-25 has been shown to increase the production of IL-9 in Th9 cells. Another function of this protein is the activation of natural lymphoid cells. IL-25 and IL-33 are the most potent activators of ILC2. IL-25 has potent antitumor activity in vivo in several human cancers including melanoma, breast, lung, colon, and pancreatic cancers, suggesting the potential clinical use of IL-17E as an anticancer agent. Recombinant human IL-17E/IL-25, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

interleukin-25 isoform 1, interleukin 25, IL17E, IL-17E, IL25, IL-25, interleukin-17E, interleukin-25, Macroprhagleukin-25 isoform 2

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Xinyang Song., et al, (2013) Cell Signal. 25:2335-2347.;; Rickel EA., et al, (2008) J Immunol. 181:4299-4310.

Purity :

> 95% by SDS - PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human IL-17 RB (CAT# ATGP4039)

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology, Hormones & Cytokines

Molecular Weight :

17.8kDa (154aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human IL-17E/IL-25 is coated at 2 ug/ml (100 ul/well) can bind Human IL-17 RB (CAT# ATGP4039) in a Functional ELISA assay.

Amino Acid Sequence :

YSHWPSC CPSKGQDTSE ELLRWSTVPV PPLEPARPNR HPESCRASED GPLNSRAISP WRYELDRDLN RLPQDLYHAR CLCPHCVSLQ TGSHMDPRGN SELLYHNQTV FYRRPCHGEK GTHKGYCLER RLYRVSLACV CVRPRVMG

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Asp

Product Type Name :

Recombinant Protein

UniProt No. :

Q9H293

Internal Search Terms :

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more info or order :

NKMAX product webpage