Recombinant human CD200 protein | NKMAX ATGP4013 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CD200 protein

catalog :

ATGP4013

quantity :

10 ug

price :

150 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CD200 protein

Domain :

31-232aa

Catalog number (SKU) :

ATGP4013

NCBI :

NP_005935

Description :

CD200, also known as OX-2 membrane glycoprotein isoform a, belongs to the immunoglobulin superfamily. This protein imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. D200 and CD200R associate via their respective N-terminal Ig-like domains. CD200-CD200R signaling have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Elevated expression of this protein has been reported to be associated with poor prognosis in a number of human malignancies. In addition, it also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion. Recombinant human CD200 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

OX-2 membrane glycoprotein isoform a, CD200, MOX1, MOX2, MRC, OX-2

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Akkaya M., et al. (2013) PLoS One. 8:e63325.;; Li L., et al. (2016) Med Sci Monit. 22:1079-1084.

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human CD200R1 (CAT# ATGP3809)

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

23.5 kDa (211aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

CD200 Subunit is coated at 10 ug/ml (100 ul/well) can bind Human CD200R1 (CAT# ATGP3809) in a Functional ELISA assay.

Amino Acid Sequence :

QVQVVTQ DEREQLYTPA SLKCSLQNAQ EALIVTWQKK KAVSPENMVT FSENHGVVIQ PAYKDKINIT QLGLQNSTIT FWNITLEDEG CYMCLFNTFG FGKISGTACL TVYVQPIVSL HYKFSEDHLN ITCSATARPA PMVFWKVPRS GIENSTVTLS HPNGTTSVTS ILHIKDPKNQ VGKEVICQVL HLGTVTDFKQ TVNKG

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P41217

Internal Search Terms :

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more info or order :

NKMAX product webpage