product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human SOST/Sclerostin protein
catalog :
ATGP4011
quantity :
10 ug
price :
150 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human SOST/Sclerostin protein
Domain :
24-213aa
Catalog number (SKU) :
ATGP4011
NCBI :
NP_079513.1
Description :
SOST, also known as Sclerostin, is a member of the cerberus/DAN family. This protein is produced primarily by the osteocyte but is also expressed in other tissues, and has anti-anabolic effects on bone formation. It was originally believed to be a nonclassical bone morphogenetic protein (BMP) antagonist. More recently, sclerostin has been identified as binding to LRP5/6 receptors and inhibiting the Wnt signaling pathway. The inhibition of the Wnt pathway leads to decreased bone formation. Although the underlying mechanisms are unclear, it is believed that the antagonism of BMP-induced bone formation by sclerostin is mediated by Wnt signaling, but not BMP signaling pathways. Mutations in the gene that encodes the sclerostin protein are associated with disorders associated with high bone mass, sclerosteosis and van Buchem disease. Recombinant human SOST/Sclerostin, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Alternative Names :
SOST, Sclerostin, UNQ2976, PRO7455, PRO7476, CDD, VBCH, DAND6, SOST1
Concentration :
0.25mg/ml (determined by Bradford assay)
Formulation :
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Winkler DG, et al. (2003) The EMBO Journal. 22:6267–6276.;; Li X, et al. (2005) The Journal of Biological Chemistry. 280:19883–19887.
Purity :
> 95% by SDS - PAGE
Applications :
SDS-PAGE
Antigen Species :
Human
Gene Category :
Signal Transduction
Molecular Weight :
22.7kDa (200aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Amino Acid Sequence :
QGWQAF KNDATEIIPE LGEYPEPPPE LENNKTMNRA ENGGRPPHHP FETKDVSEYS CRELHFTRYV TDGPCRSAKP VTELVCSGQC GPARLLPNAI GRGKWWRPSG PDFRCIPDRY RAQRVQLLCP GGEAPRARKV RLVASCKCKR LTRFHNQSEL KDFGTEAARP QKGRKPRPRA RSAKANQAEL ENAY
Tag :
His-Tag
Expression System :
HEK293
Predicted nterm :
Asp
Product Type Name :
Recombinant Protein
UniProt No. :
Q9BQB4
Internal Search Terms :
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more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.