Recombinant human DC-SIGN/CD209 protein | NKMAX ATGP4010 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human DC-SIGN/CD209 protein

catalog :

ATGP4010

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human DC-SIGN/CD209 protein

Domain :

60-404aa

Catalog number (SKU) :

ATGP4010

NCBI :

NP_066978

Description :

DC-SIGN/CD209, also known as Dendritic Cell-specific ICAM-3 Grabbing Non-integrin, is a member of the C-type lectin family. It is Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of pathogen associated molecular patterns PAMPs commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. It has a high affinity for the ICAM3 molecule and binds various microorganisms by recognizing high-mannose-containing glycoproteins on their envelopes and especially functions as receptor for several viruses such as HIV and Hepatitis C. Besides functioning as an adhesion molecule, recent study has also shown that DC-SIGN can initiate innate immunity by modulating toll-like receptors, though the detailed mechanism is not yet known. It together with other C-type lectins is involved in recognition of tumors by dendritic cells. It is also a potential engineering target for dendritic cell based cancer vaccine. Recombinant human DC-SIGN/CD209, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

CDSIGN, CLEC4L, CD209 antigen isoform 1, CD209 antigen, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN, DC-SIGN1, CD_antigen, CD209

Concentration :

0.25mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Liu, W. et al, (2004) J. Biol. Chem. 279:18748.;; Anthony, R.M. et al, (2008) Proc. Natl. Acad. Sci. USA 105:19571.

Purity :

> 90% by SDS - PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

66.5kDa (587aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

VSKVPSS ISQEQSRQDA IYQNLTQLKA AVGELSEKSK LQEIYQELTQ LKAAVGELPE KSKLQEIYQE LTRLKAAVGE LPEKSKLQEI YQELTWLKAA VGELPEKSKM QEIYQELTRL KAAVGELPEK SKQQEIYQEL TRLKAAVGEL PEKSKQQEIY QELTRLKAAV GELPEKSKQQ EIYQELTQLK AAVERLCHPC PWEWTFFQGN CYFMSNSQRN WHDSITACKE VGAQLVVIKS AEEQNFLQLQ SSRSNRFTWM GLSDLNQEGT WQWVDGSPLL PSFKQYWNRG EPNNVGEEDC AEFSGNGWND DKCNLAKFWI CKKSAASCSR DEEQFLSPAP ATPNPPPA

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

UniProt No. :

Q9NNX6

Internal Search Terms :

ATGP4010-10ug,ATGP4010-20ug,ATGP4010-50ug,ATGP4010-100ug,ATGP4010-250ug,ATGP4010-500ug,ATGP4010-1mg,ATGP4010-10,ATGP4010-20,ATGP4010-50,ATGP4010-100,ATGP4010-250,ATGP4010-500,ATGP4010-1,ATGP4010-10ug,ATGP4010-20ug,ATGP4010-50ug,ATGP4010-100ug,ATGP4010-250ug,ATGP4010-500ug,ATGP4010-1mg,ATGP4010-10,ATGP4010-20,ATGP4010-50,ATGP4010-100,ATGP4010-250,ATGP4010-500,ATGP4010-1

more info or order :

NKMAX product webpage