Recombinant human ULBP-3 protein | NKMAX ATGP4009 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human ULBP-3 protein

catalog :

ATGP4009

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human ULBP-3 protein

Domain :

30-217aa

Catalog number (SKU) :

ATGP4009

NCBI :

NP_078794

Description :

ULBP-3, also known as NKG2D ligand 3, is ligands for natural-killer group 2, member D (NKG2D) receptor. It is related to MHC class I molecules, but its gene maps outside the MHC locus. The domain structure of ULBP3 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP3 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor. It functions as a stress-induced ligand for NKG2D receptor. In the normal hair follicle, ULBP3 is turned off. However, different studies reported its high level in alopecia areata (AA). It is also expressed on some tumor cells and have been implicated in tumor surveillance. Recombinant human ULBP-3, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

NKG2D ligand 3, UL16 binding protein 3, N2DL-3, NKG2DL3, RAET1N, ALCAN-gamma, Retinoic acid early transcript 1N

Concentration :

1mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Moftah NH, et al, (2016) Arch Dermatol Res. 308:415-421.;; Wirsching HG, et al, (2019) JCI Insight. 4:e128217.

Purity :

> 95% by SDS - PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

49.3kDa (430aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

DAHSLWY NFTIIHLPRH GQQWCEVQSQ VDQKNFLSYD CGSDKVLSMG HLEEQLYATD AWGKQLEMLR EVGQRLRLEL ADTELEDFTP SGPLTLQVRM SCECEADGYI RGSWQFSFDG RKFLLFDSNN RKWTVVHAGA RRMKEKWEKD SGLTTFFKMV SMRDCKSWLR DFLMHRKKRL EPTAPPTMAP G

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q9BZM4

Internal Search Terms :

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more info or order :

NKMAX product webpage