Recombinant human CD40/TNFRSF5 protein | NKMAX ATGP4007 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CD40/TNFRSF5 protein

catalog :

ATGP4007

quantity :

10 ug

price :

136 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CD40/TNFRSF5 protein

Domain :

21-193aa

Catalog number (SKU) :

ATGP4007

NCBI :

NP_001241.1

Description :

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily. It transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglubiln secretion. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells. Recombinant human CD40, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, p50, CD40L receptor, CDw40

Concentration :

1mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Vonderheide RH, et al, (2013) Clin Cancer Res. 19:1035-1043.;; Remer M., et al (2017) Curr Top Microbiol Immunol. 405:165-207.;; Karnell JL, et al, (2019) Adv Drug Deliv Rev. 141:92-103.;;

Purity :

> 95% by SDS - PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

46.1kDa (412aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLR

Tag :

hIgG-His-Tag

Expression System :

HEK293

Predicted nterm :

Glu 21

Product Type Name :

Recombinant Protein

UniProt No. :

P25942

Internal Search Terms :

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more info or order :

NKMAX product webpage