Recombinant human Thrombomodulin/BDCA-3 protein | NKMAX ATGP3996 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Thrombomodulin/BDCA-3 protein

catalog :

ATGP3996

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Thrombomodulin/BDCA-3 protein

Domain :

22-515aa

Catalog number (SKU) :

ATGP3996

NCBI :

NP_000352

Description :

Thrombomodulin, also known as CD141 or BDCA-3, is an endothelial cell-expressed, transmembrane glycoprotein that can form a complex with the coagulation factor, thrombin. This complex induce activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin-bound thrombin has procoagulant effect at the same time by inhibiting fibrinolysis by cleaving thrombin-activatable fibrinolysis inhibitor (TAFI) into its active form. Reduced levels of thrombomodulin or increased serum levels of THBD can correlate with pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. In addition, It associated with liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis. Recombinant human Thrombomodulin, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

THBD, Thrombomodulin, TM, Fetomodulin, CD141, CD141 antigen, THRM, BDCA-3, BDCA3, blood dendritic cell antigen 3, AHUS6, THPH12

Concentration :

0.5mg/ml (determined by Bradford assay)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Bajzar L, Morser J, Nesheim M (1996). The Journal of Biological Chemistry. 271: 16603–16608.;; Jakubowski HV, Owen WG (1989). The Journal of Biological Chemistry. 264: 11117–11121.;; Weiler, H. and B.H. Isermann (2003) J. Thromb. Haemost. 1:1515-1524.;; Califano, F. et al. (2000) Eur. Rev. Med. Pharmacol. Sci. 4:59-66.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cardiovascular

Molecular Weight :

52.6kDa(500aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

EPQPGGSQCV EHDCFALYPG PATFLNASQI CDGLRGHLMT VRSSVAADVI SLLLNGDGGV GRRRLWIGLQ LPPGCGDPKR LGPLRGFQWV TGDNNTSYSR WARLDLNGAP LCGPLCVAVS AAEATVPSEP IWEEQQCEVK ADGFLCEFHF PATCRPLAVE PGAAAAAVSI TYGTPFAARG ADFQALPVGS SAAVAPLGLQ LMCTAPPGAV QGHWAREAPG AWDCSVENGG CEHACNAIPG APRCQCPAGA ALQADGRSCT ASATQSCNDL CEHFCVPNPD QPGSYSCMCE TGYRLAADQH RCEDVDDCIL EPSPCPQRCV NTQGGFECHC YPNYDLVDGE CVEPVDPCFR ANCEYQCQPL NQTSYLCVCA EGFAPIPHEP HRCQMFCNQT ACPADCDPNT QASCECPEGY ILDDGFICTD IDECENGGFC SGVCHNLPGT FECICGPDSA LARHIGTDCD SGKVDGGDSG SGEPPPSPTP GSTLTPPAVG LVHS

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Glu22

Product Type Name :

Recombinant Protein

UniProt No. :

P07204

Internal Search Terms :

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more info or order :

NKMAX product webpage