product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant mouse TIM-3/HAVCR2 protein
catalog :
ATGP3992
quantity :
10 ug
price :
110 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant mouse TIM-3/HAVCR2 protein
Domain :
20-193aa
Catalog number (SKU) :
ATGP3992
NCBI :
NP_599011.2
Description :
TIM-3, also known as HAVCR2(epatitis A virus cellular receptor 2), belongs to TIM family cell surface receptor proteins.TIM-3 is up‑regulated on several populations of activated myeloid cells and T cells. It is an immune checkpoint and together with other inhibitory receptors including PD-1and LAG3 mediate the CD8+ T-cell exhaustion. Also, it is primarily activated by galectin-9. The engagement leads to stimulation of an influx of calcium to intracellular space and induction of programmed cell death, apoptosis. As a consequence, a suppression of Th1 and Th17 responses and induction of immune tolerance occurs. Recombinant mouse TIM-3, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Alternative Names :
Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, CD366
Concentration :
0.5mg/ml (determined by Absorbance at 280nm)
Formulation :
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Ana C Anderson., et al, (2016) Immunity. 44:989-1004.;; Ruihan Tang., et al, (2019) Semin Immunol. 42:101302.;; Huang YH., (2015) Nature. 517:386–390.
Purity :
> 95% by SDS - PAGE
Applications :
SDS-PAGE
Antigen Species :
Human, Mouse
Gene Category :
Immunology
Molecular Weight :
46.3kDa (413aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Amino Acid Sequence :
RSLENAYVFE VGKNAYLPCS YTLSTPGALV PMCWGKGFCP WSQCTNELLR TDERNVTYQK SSRYQLKGDL NKGDVSLIIK NVTLDDHGTY CCRIQFPGLM NDKKLELKLD IKAAKVTPAQ TAHGDSTTAS PRTLTTERNG SETQTLVTLH NNNGTKISTW ADEIKDSGET IRTA
Tag :
hIgG-His-Tag
Expression System :
HEK293
Predicted nterm :
Arg20
Product Type Name :
Recombinant Protein
UniProt No. :
Q8VIM0
Internal Search Terms :
CD366, Hepatitis A virus cellular receptor 2 homolog, T cell immunoglobulin and mucin domain-containing protein 3, T cell immunoglobulin mucin receptor 3, T cell membrane protein 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM 3, TIM3, TIM-3, TIMD 3, TIMD3, TIMD-3, ATGP3992-10ug, ATGP3992-20ug, ATGP3992-50ug, ATGP3992-100ug, ATGP3992-250ug, ATGP3992-500ug, ATGP3992-1mg, ATGP3992-010, ATGP3992-020, ATGP3992-050, ATGP3992-100, ATGP3992-250, ATGP3992-500, ATGP3992-01M
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.