Recombinant human NCAM-1/CD56 protein | NKMAX ATGP3991 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human NCAM-1/CD56 protein

catalog :

ATGP3991

quantity :

10 ug

price :

110 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human NCAM-1/CD56 protein

Domain :

20-603aa

Catalog number (SKU) :

ATGP3991

NCBI :

NP_001070150

Description :

NCAM-1, also known as CD56, is a member of the immunoglobulin superfamily. It specifically binds to neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. The polysialyation of NCAM-1 reduces its adhesive property and increases its neurite outgrowth promoting features. It has also been shown to be involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. This protein is preferentially expressed in NK cells and a subset of T lymphocytes that mediate MHC-unrestricted cell-mediated cytotoxicity. High expression of NCAM-1/CD56 differentiates NK cells as having an activated phenotype. CD56(+high) NK cells mediate heightened effector functions in response to IL-12. During hematopoiesis, NCAM-1/CD56 is the prototypic marker of NK cells, also present on subset of CD4+ T cells and CD8+ T cells. In cell adhesion, it contributes to cell-cell adhesion or cell-matrix adhesion during embryonic development. In anatomic pathology, pathologists make use of it immunohistochemistry to recognize certain tumors. Recombinant human NCAM-1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Neural cell adhesion molecule 1, Neural cell adhesion molecule 1 isoform3, N-CAM-1, NCAM-1, NCAM, NCAM1, CD56 antigen, CD56, MSK39, NCAM

Concentration :

1mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Van Acker HH, et al. (2017). Frontiers in Immunology. 8:892.;; Sanchez-Heras, E. et al. (2006) J Biol Chem. 281:35208-35216.

Purity :

> 95% by SDS - PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

65.7kDa(593aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

LQVDIVP SQGEISVGES KFFLCQVAGD AKDKDISWFS PNGEKLTPNQ QRISVVWNDD SSSTLTIYNA NIDDAGIYKC VVTGEDGSES EATVNVKIFQ KLMFKNAPTP QEFREGEDAV IVCDVVSSLP PTIIWKHKGR DVILKKDVRF IVLSNNYLQI RGIKKTDEGT YRCEGRILAR GEINFKDIQV IVNVPPTIQA RQNIVNATAN LGQSVTLVCD AEGFPEPTMS WTKDGEQIEQ EEDDEKYIFS DDSSQLTIKK VDKNDEAEYI CIAENKAGEQ DATIHLKVFA KPKITYVENQ TAMELEEQVT LTCEASGDPI PSITWRTSTR NISSEEKTLD GHMVVRSHAR VSSLTLKSIQ YTDAGEYICT ASNTIGQDSQ SMYLEVQYAP KLQGPVAVYT WEGNQVNITC EVFAYPSATI SWFRDGQLLP SSNYSNIKIY NTPSASYLEV TPDSENDFGN YNCTAVNRIG QESLEFILVQ ADTPSSPSID QVEPYSSTAQ VQFDEPEATG GVPILKYKAE WRAVGEEVWH SKWYDAKEAS MEGIVTIVGL KPETTYAVRL AALNGKGLGE ISAASEFKTQ PVHSPPP

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P13591

Internal Search Terms :

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more info or order :

NKMAX product webpage