Recombinant human NRG1/HRG1 protein | NKMAX ATGP3990 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human NRG1/HRG1 protein

catalog :

ATGP3990

quantity :

10 ug

price :

94 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human NRG1/HRG1 protein

Domain :

20-241aa

Catalog number (SKU) :

ATGP3990

NCBI :

NP_039252

Description :

Neuregulin-1 (NRG1), also known as ARIA, is one of four proteins in the neuregulin family that act on the EGFRfamily of receptors. It has multiple isoforms that aregenerated by usage of different promoters and alternative splicing of a single gene. This protein regulates multiple nervous system functions including axon guidance, synapse formation and plasticity, glial cell development, and axon myelination. In the heart, it regulates organ morphogenesis and contractility and also plays a cardioprotective role following tissue injury. NRG1 is essential for the development and function of multiple organ systems, and itsdysregulation has been linked to diseases such as cancer and schizophrenia. Recombinant human NRG1,fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatographytechniques.

Alternative Names :

NRG1, ARIA, GGF2, GGF, GGFglial growth factor, HGL, HGLneu differentiation factor, HRG, HRG1, HRGA, NRG-IT2, NRG1-IT2, HRG1-alpha, HRG1-beta 1, HRGAneuregulin 1 type IV beta 1a, Heregulin-1, MST131, MSTP131, NDFheregulin, alpha (45kD, ERBB2 p185-activator), Neuregulin-1, Neuregulin1, SMDF, neuregulin 1, neuregulin 1 type IV beta 3, pro-NRG1, pro-neuregulin-1, membrane-bound isoform, sensory and motor neuron derived factor

Concentration :

0.5mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Tan W, et al. (2007). J Biol Chem. 282:24343-24351.;; Nicodemus KK, et al. (2010). Arch Gen Psychiatry. 67:991-1001.

Purity :

> 90% by SDS - PAGE

Bioactivity Comment Only :

Measured in a cell proliferation assay using MCF7 human breast cancer cell. The ED50 range ≤ 15 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

25.1kDa(231aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human Proinsulin in a cell proliferation assay using MCF7 human breast cancer cell. The ED50 range ≤ 15 ng/ml.

Amino Acid Sequence :

SGKKPES AAGSQSPALP PRLKEMKSQE SAAGSKLVLR CETSSEYSSL RFKWFKNGNE LNRKNKPQNI KIQKKPGKSE LRINKASLAD SGEYMCKVIS KLGNDSASAN ITIVESNEII TGMPASTEGA YVSSESPIRI SVSTEGANTS SSTSTSTTGT SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYSTSTPF LSLPE

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q02297

Internal Search Terms :

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more info or order :

NKMAX product webpage