Recombinant human FOLR2 protein | NKMAX ATGP3987 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human FOLR2 protein

catalog :

ATGP3987

quantity :

10 ug

price :

130 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human FOLR2 protein

Domain :

22-230aa

Catalog number (SKU) :

ATGP3987

NCBI :

NP_000794.3

Description :

FOLR2, also known as Folate receptor beta, is a member of the folate receptor (FLOR) family. Members of this gene family have a high affinity for folate and folic acid analogs at neutral pH. And they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. It was originally thought to exist only in placenta, but is also expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. FOLR2 is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. Recombinant human FOLR2, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FBP Protein, BETA-HFR Protein, FBP/PL-1 Protein, FR-BETA Protein, FR-P3 Protein, FRbeta, FR-BETA, FBP/PL-1, BETA-HFR

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Ross, J.F. et al.,1994, Cancer 73:2432.;; Joost W van der Heijden J.W. et al., 2009, Arthritis Rheum. 60:12-21.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Folic Acid-BSA. The ED50 range ≤ 5 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Signal Transduction, Metabolism

Molecular Weight :

25.1 kDa (215aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Folic Acid-BSA is coated at 10ug/ml (100 ul/well) can bind Human FOLR2. The ED50 range ≤ 5 ug/ml.

Amino Acid Sequence :

QDRTDLLNVC MDAKHHKTKP GPEDKLHDQC SPWKKNACCT ASTSQELHKD TSRLYNFNWD HCGKMEPACK RHFIQDTCLY ECSPNLGPWI QQVNQSWRKE RFLDVPLCKE DCQRWWEDCH TSHTCKSNWH RGWDWTSGVN KCPAGALCRT FESYFPTPAA LCEGLWSHSY KVSNYSRGSG RCIQMWFDSA QGNPNEEVAR FYAAAMHVN

Tag :

His-Tag

Expression System :

HEK293

Predicted nterm :

Gln 22

Product Type Name :

Recombinant Protein

UniProt No. :

P14207

Internal Search Terms :

,ATGP3987-10ug,ATGP3987-20ug,ATGP3987-50ug,ATGP3987-100ug,ATGP3987-250ug,ATGP3987-500ug,ATGP3987-1mg,ATGP3987-10,ATGP3987-20,ATGP3987-50,ATGP3987-100,ATGP3987-250,ATGP3987-500,ATGP3987-1

more info or order :

NKMAX product webpage