Recombinant human pIgR protein | NKMAX ATGP3978 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human pIgR protein

catalog :

ATGP3978

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human pIgR protein

Domain :

19-638aa

Catalog number (SKU) :

ATGP3978

NCBI :

NP_002635

Description :

pIgR, also known as polymeric immunoglobulin receptor, is responsible for transcytosis of soluble dimeric IgAs and immune. This protein binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, the cleavage occurs that separates the extracellular from the transmembrane segment. PIgR expression is under the strong regulation of cytokines, hormones, and pathogenic stimuli. The expression of pIgR is critically regulated by the pro-inflammatory cytokines, such as IL-1, IL-4, TNF-α, and IFN-γ. Recombinant human pIgR, fused to Histag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Polymeric immunoglobulin receptor, PIGR, PIgR, Poly-Ig receptor, Hepatocellular carcinoma-associated protein TB6, polymeric immunoglobulin receptor precursor

Concentration :

1mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Giffroy D, et al, (2001) Scand J Immunol. 53:56-64.;; Kortum AN, et al, (2014) Immunogenetics. 66:267-279.;; Yue X, et al, (2017) Hepatolgoy. 65:1948-1962.;;

Purity :

> 95% by SDS - PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human IgM. The ED50 range ≤10 ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

68.9kDa (629aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human IgM is coated at 2 ug/ml (100 ul/well) can bind Human pIgR. The ED50 range ≤10 ug/ml.

Amino Acid Sequence :

KSPIFGP EEVNSVEGNS VSITCYYPPT SVNRHTRKYW CRQGARGGCI TLISSEGYVS SKYAGRANLT NFPENGTFVV NIAQLSQDDS GRYKCGLGIN SRGLSFDVSL EVSQGPGLLN DTKVYTVDLG RTVTINCPFK TENAQKRKSL YKQIGLYPVL VIDSSGYVNP NYTGRIRLDI QGTGQLLFSV VINQLRLSDA GQYLCQAGDD SNSNKKNADL QVLKPEPELV YEDLRGSVTF HCALGPEVAN VAKFLCRQSS GENCDVVVNT LGKRAPAFEG RILLNPQDKD GSFSVVITGL RKEDAGRYLC GAHSDGQLQE GSPIQAWQLF VNEESTIPRS PTVVKGVAGG SVAVLCPYNR KESKSIKYWC LWEGAQNGRC PLLVDSEGWV KAQYEGRLSL LEEPGNGTFT VILNQLTSRD AGFYWCLTNG DTLWRTTVEI KIIEGEPNLK VPGNVTAVLG ETLKVPCHFP CKFSSYEKYW CKWNNTGCQA LPSQDEGPSK AFVNCDENSR LVSLTLNLVT RADEGWYWCG VKQGHFYGET AAVYVAVEER KAAGSRDVSL AKADAAPDEK VLDSGFREIE NKAIQDPRLF AEEKAVADTR DQADGSRASV DSGSSEEQGG SSR

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P01833

Internal Search Terms :

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more info or order :

NKMAX product webpage