product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant canine IL-1 alpha/IL1A protein
catalog :
ATGP3976
quantity :
10 ug
price :
140 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant canine IL-1 alpha/IL1A protein
Domain :
109-265aa
Catalog number (SKU) :
ATGP3976
NCBI :
NP_001003157
Description :
IL-1 alpha /IL-1F1, also known as hematopoietin 1 is a cytokine of the interleukin 1 family. IL-1α is a unique member in the cytokine family in the sense that the structure of its initially synthesized precursor does not contain a signal peptide fragment. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1 alpha inhibitors are being developed to interrupt those processes and treat diseases. IL-1 alpha is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. Although IL-1 production is generally considered to be a consequence of inflammation, recent evidence suggests that IL-1 is also temporarily upregulated during bone formation and the menstrual cycle and can be induced in response to nervous system stimulation. Recombinant canine IL-1 alpha /IL-1F1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Alternative Names :
IL-1 alpha, Il-1a, Interleukin 1 alpha, Interleukin-1 alpha precursor
Concentration :
0.25mg/ml (determined by Absorbance at 280nm)
Formulation :
Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Watanabe N., et al, (1994) Cytokine. 6:597–601.;; Nicklin MJ., et al, (1994) Genomics. 19:382–384.;; March CJ, Mosley B., et al, (1985). Nature. 315 : 641–647.
Purity :
> 90% by SDS - PAGE
Bioactivity Comment Only :
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cell. The ED50 range ≤ 2 ng/ml.
Applications :
SDS-PAGE, Bioactivity
Antigen Species :
Canine
Gene Category :
Immunology
Molecular Weight :
19.3kDa (166aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Bioactivity Comment and Pics :
Canine IL-1 alpha/IL-1F1 in a cell proliferation assay using D10.G4.1 mouse helper T cell. The ED50 range ≤ 2 ng/ml.
Amino Acid Sequence :
SVAYNFH NNEKYNYIRI IKSQFILNDN LNQSIVRQTG GNYLMTAALQ NLDDAVKFDM GAYTSEDSKL PVTLRISKTR LFVSAQNEDE PVLLKEMPET PKTIRDETNL LFFWERHGSK HYFKSVAQPK LFIATQERKL VHMARGQPSI TDFRLLETQP
Tag :
His-Tag
Expression System :
Baculovirus
Predicted nterm :
Ala
Product Type Name :
Recombinant Protein
UniProt No. :
O46612
Internal Search Terms :
IL 1 alpha, IL1 alpha, IL-1 alpha, Il-1a, Il1a, Il 1a, Interleukin 1 alpha, Interleukin-1 alpha precursor, ATGP3976-10ug, ATGP3976-20ug, ATGP3976-50ug, ATGP3976-100ug, ATGP3976-250ug, ATGP3976-500ug, ATGP3976-1mg, ATGP3976-010, ATGP3976-020, ATGP3976-050, ATGP3976-100, ATGP3976-250, ATGP3976-500, ATGP3976-01M
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.