Recombinant mouse LIFR alpha/LIFR Protein | NKMAX ATGP3958 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant mouse LIFR alpha/LIFR Protein

catalog :

ATGP3958

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant mouse LIFR alpha/LIFR Protein

Domain :

44-828aa

Catalog number (SKU) :

ATGP3958

NCBI :

NP_038612

Description :

LIFR alpha, also known as CD118, is a member of the Interleukin-6 receptor family. Members of this family mediate the biological effects of Cardiotrophin-1, CLC, CNTF, IL-6, IL-11, IL-27, and Oncostatin M. The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIFR alpha has also been identified as a breast cancer metastasis suppressor that functions through the HIPPO-YAP pathway. LIFR alpha is down regulated in a number of breast carcinomas and may serve a prognostic tool. Recombinant mouse LIFR alpha, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Leukemia inhibitory factor receptor, LIF receptor, LIF-R, LIF receptor subunit alpha, D-factor, CD118

Concentration :

0.25mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Gearing DP., et al (1991) The EMBO Journal. 10: 2839–2848.;; Layton MJ., et al. (1992) Proc. Natl. Acad. Sci. 89:8616.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its ability to inhibit proliferation using TF-1 human erythroleukemic cells. The ED50 range ≤ 1ug/ml with Mouse LIF.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Mouse

Gene Category :

Immunology

Molecular Weight :

89.6kDa (794aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Mouse LIFR alpha inhibits human LIF (Cat# ATGP3533) induced cell proliferation in the TF-1 human erythroleukemic cells. The ED50 range is ≤ 1 ug/ml.

Amino Acid Sequence :

LKRGVQD LKCTTNNMRV WDCTWPAPLG VSPGTVKDIC IKDRFHSCHP LETTNVKIPA LSPGDHEVTI NYLNGFQSKF TLNEKDVSLI PETPEILDLS ADFFTSSLLL KWNDRGSALP HPSNATWEIK VLQNPRTEPV ALVLLNTMLS GKDTVQHWNW TSDLPLQCAT HSVSIRWHID SPHFSGYKEW SDWSPLKNIS WIRNTETNVF PQDKVVLAGS NMTICCMSPT KVLSGQIGNT LRPLIHLYGQ TVAIHILNIP VSENSGTNII FITDDDVYGT VVFAGYPPDV PQKLSCETHD LKEIICSWNP GRITGLVGPR NTEYTLFESI SGKSAVFHRI EGLTNETYRL GVQMHPGQEI HNFTLTGRNP LGQAQSAVVI NVTERVAPHD PTSLKVKDIN STVVTFSWYL PGNFTKINLL CQIEICKANS KKEVRNATIR GAEDSTYHVA VDKLNPYTAY TFRVRCSSKT FWKWSRWSDE KRHLTTEATP SKGPDTWREW SSDGKNLIVY WKPLPINEAN GKILSYNVSC SLNEETQSVL EIFDPQHRAE IQLSKNDYII SVVARNSAGS SPPSKIASME IPNDDITVEQ AVGLGNRIFL TWRHDPNMTC DYVIKWCNSS RSEPCLLDWR KVPSNSTETV IESDQFQPGV RYNFYLYGCT NQGYQLLRSI IGYVEELAPI VAPNFTVEDT SADSILVKWD DIPVEELRGF LRGYLFYFQK GERDTPKTRS LEPHHSDIKL KNITDISQKT LRIADLQGKT SYHLVLRAYT HGGLGPEKSM FVVTKENS

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Leu

Product Type Name :

Recombinant Protein

UniProt No. :

P42703

Internal Search Terms :

,ATGP3958-10ug,ATGP3958-20ug,ATGP3958-50ug,ATGP3958-100ug,ATGP3958-250ug,ATGP3958-500ug,ATGP3958-1mg,ATGP3958-10,ATGP3958-20,ATGP3958-50,ATGP3958-100,ATGP3958-250,ATGP3958-500,ATGP3958-1

more info or order :

NKMAX product webpage