Recombinant Human IFN-alpha/beta R2/IFNAR2 protein | NKMAX ATGP3952 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant Human IFN-alpha/beta R2/IFNAR2 protein

catalog :

ATGP3952

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant Human IFN-alpha/beta R2/IFNAR2 protein

Domain :

27-243aa

Catalog number (SKU) :

ATGP3952

NCBI :

NP_997468

Description :

IFN-alpha/beta R2, also known as IFNAR2, is a member of the class II cytokine receptor family. This protein is the principal ligand binding subunit of the receptor. Ligand bindnig is stabilized by the subsequent association with IFNAR1 and forms the signaling compelx recptor. It also plays the role in STAT1, STAT2, and STAT3 activation. Recombinant human IFN-alpha/beta R2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interferon alpha/beta receptor 2, IFNAR2, IFN-alpha binding protein, Interferon alpha binding protein, Type I interferon receptor 2, interferon alpha/beta receptor 2 isoform a, IFN-R-2, IFNABR, IFNARB, IFN-alpha-REC, IFN-R, IMD45

Concentration :

0.25mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Grazziola C, et al, (2005) Int J Oncol 26:129-140.;; Ortiz A, et al, (2019) Cancer Cell 35:33-45.;;

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its binding ability in a functional ELISA with Human IFN-alpha 2 (CAT# IFN0502) in the presence of Human IFN-alpha/beta R1 (CAT# ATGP3894). The ED50 range ≤ 500 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology, Hormones & Cytokines

Molecular Weight :

51.7kDa (456aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human IFN-alpha 2 (CAT# IFN0502) is coated at 10 ug/ml (100 ul/well) can bind Human IFN-alpha/beta R2 in the presence of Human IFN-alpha/beta R1 (CAT# ATGP3894). The ED50 range ≤ 500 ng/ml.

Amino Acid Sequence :

ISYDSPDYTD ESCTFKISLR NFRSILSWEL KNHSIVPTHY TLLYTIMSKP EDLKVVKNCA NTTRSFCDLT DEWRSTHEAY VTVLEGFSGN TTLFSCSHNF WLAIDMSFEP PEFEIVGFTN HINVMVKFPS IVEEELQFDL SLVIEEQSEG IVKKHKPEIK GNMSGNFTYI IDKLIPNTNY CVSVYLEHSD EQAVIKSPLK CTLLPPGQES ESAESAK

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ile

Product Type Name :

Recombinant Protein

UniProt No. :

P48551

Internal Search Terms :

,ATGP3952-10ug,ATGP3952-20ug,ATGP3952-50ug,ATGP3952-100ug,ATGP3952-250ug,ATGP3952-500ug,ATGP3952-1mg,ATGP3952-10,ATGP3952-20,ATGP3952-50,ATGP3952-100,ATGP3952-250,ATGP3952-500,ATGP3952-1

more info or order :

NKMAX product webpage