Recombinant Rat UNC5H2/UNC5B protein | NKMAX ATGP3950 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant Rat UNC5H2/UNC5B protein

catalog :

ATGP3950

quantity :

10 ug

price :

150 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant Rat UNC5H2/UNC5B protein

Domain :

27-373aa

Catalog number (SKU) :

ATGP3950

NCBI :

NP_071543

Description :

UNC5B/UNC5B, also known as Netrin receptor UNC5B, is one of four related receptors that comprise the UNC5 family and serve as receptors for the axon guidance molecule Netrin-1. Outside of the nervous system, UNC5B facilitates Netrin-1-mediated inhibition of capillary branching and leukocyte migration, as well as Netrin-1-mediated promotion of osteoclast differentiation. Also this protein activates DAPK1 which mediates apoptosis. It is believed to play a role in tumorgenesis. Additionally, It is thought to play a critical role in the development of atherosclerosis and the survival of renal tubular epithelial cells during acute kidney injury. Recombinant Rat UNC5B/UNC5B, fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Alternative Names :

unc-5 netrin receptor B, Unc5h2, unc-5 homolog 2, Protein unc-5 homolog B, netrin receptor UNC5B precursor, netrin receptor UNC5B, protein unc-5 homolog 2, unc5b

Concentration :

0.25mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Bhat SA, et al, (2019) J Cell Commun Signal. 13:121-127.;; Mediero A, et al, (2016) FASEB J. 30:3835-3844.;; Liu J, et al, (2013) Tumour Biol. 34:2099-2108.;;

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Rat

Gene Category :

Signal Transduction

Molecular Weight :

66.0kDa (590aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

GIDSGG QALPDSFPSA PAEQLPHFLL EPEDAYIVKN KPVELHCRAF PATQIYFKCN GEWVSQKGHV TQESLDEATG LRIREVQIEV SRQQVEELFG LEDYWCQCVA WSSSGTTKSR RAYIRIAYLR KNFDQEPLAK EVPLDHEVLL QCRPPEGVPV AEVEWLKNED VIDPAQDTNF LLTIDHNLII RQARLSDTAN YTCVAKNIVA KRRSTTATVI VYVNGGWSSW AEWSPCSNRC GRGWQKRTRT CTNPAPLNGG AFCEGQACQK TACTTVCPVD GAWTEWSKWS ACSTECAHWR SRECMAPPPQ NGGRDCSGTL LDSKNCTDGL CVLNQRTLND PKSRPLEPSG D

Tag :

hIgG-His-Tag

Expression System :

HEK293

Predicted nterm :

Asp

Product Type Name :

Recombinant Protein

UniProt No. :

O08722

Internal Search Terms :

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more info or order :

NKMAX product webpage