Recombinant Human Placental Lactogen/CSH1 Protein | NKMAX ATGP3948 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant Human Placental Lactogen/CSH1 Protein

catalog :

ATGP3948

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant Human Placental Lactogen/CSH1 Protein

Domain :

27-217aa

Catalog number (SKU) :

ATGP3948

NCBI :

NP_001308

Description :

CSH1, also known as placental lactogen, is a member of the PRL/GH family. CSH1 gene is located on chromosome 17q which participates in the regulation of postnatal and intrauterine growth. This protein is produced only during preganancy and plays important role in increase of pancreatic islets. It also inhibits apoptosis of insulinoma cell lines by activating the phosphorylation of AKT protein. CSH1 activates PRLR through zinc-induced dimerization but does not interact with GHR. Recombinant human CSH1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

chorionic somatomammotropin hormone 1 precursor, chorionic somatomammotropin A, choriomammotropin, placental lactogen, PL, chorionic somatomammotropin-1, Lactogen, CS-1, CSA, CSMT, CHB3, hcs-1, hcs-A, CSH1

Concentration :

0.25mg/ml (determined by Absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 30% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Prager S., et al, (2003) Genet Test. 7:259-263.;; Uemura S, et al, (2007) J Biol Chem. 282:8613-8621.;; Awonuga AO, et al, (2011) Mol Reprod Dev. 78:519-528.;;

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured in a cell proliferation assay using Nb2-11 Rat lymphoma cells. The ED50 range ≤ 0.8 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Signal Transduction, Hormones & Cytokines

Molecular Weight :

23.1kDa (197aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human CSH1 stimulates cell proliferation of the Nb2-11 Rat lymphoma cells. The ED50 range ≤ 0.8 ng/ml.

Amino Acid Sequence :

VQTVPLSRLF DHAMLQAHRA HQLAIDTYQE FEETYIPKDQ KYSFLHDSQT SFCFSDSIPT PSNMEETQQK SNLELLRISL LLIESWLEPV RFLRSMFANN LVYDTSDSDD YHLLKDLEEG IQTLMGRLED GSRRTGQILK QTYSKFDTNS HNHDALLKNY GLLYCFRKDM DKVETFLRMV QCRSVEGSCG F

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Val

Product Type Name :

Recombinant Protein

UniProt No. :

P0DML2

Internal Search Terms :

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more info or order :

NKMAX product webpage