Recombinant human IL-1Ra/IL1RN protein | NKMAX ATGP3934 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-1Ra/IL1RN protein

catalog :

ATGP3934

quantity :

10 ug

price :

70 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-1Ra/IL1RN protein

Domain :

26-177aa

Catalog number (SKU) :

ATGP3934

NCBI :

NP_776214

Description :

IL-1RA/IL-1F3, also known as interleukin-1 receptor antagonist, is a glycosylated protein and a powerful anti-inflammatory agent. IL‐1RA is a pan‐physiological inhibitor of IL‐1 that prevents the activation of IL‐1 receptors by inhibiting IL‐1 binding to its receptors. It can inhibit angiogenesis by blocking the activation of the IL‐1α/PI3K/NF‐κB pathway in IL‐1‐producing human colon cancer cells. Also, Several autoimmune and inflammatory diseases have been associated with an allelic polymorphism of the IL-1RA. Recombinant human IL-1RA was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor, IL1F3, IL1RA

Concentration :

1mg/ml (determined by Bradford assay)

Formulation :

Liquid. In Phosphate-Buffered Saline (pH7.4)

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Capper., et al. (2004) Clin. Exp. Immunol. 138:348;;Roberge CJ., et al. (1994) Journal of Immunology. 152: 5485-94;;Carter DB., et al. (1990) Nature. 344: 633-7

Purity :

> 95% by SDS - PAGE

Bioactivity Comment Only :

The activity is determined by the IFN-g ELISA in a using NK-92 human natural killer cells. The ED50 range ≤10 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Hormones & Cytokines

Molecular Weight :

17.2 kDa (153aa), confirmed by MALDI-TOF

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human IL-1ra/IL-1F3 stimulates IFN-g secretion of the NK-92 human natural killer cells. The ED50 range ≤10 ng/ml.

Amino Acid Sequence :

MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

Tag :

Non-Tagged

Expression System :

E.coli

UniProt No. :

P18510

Internal Search Terms :

DIRA, IL1F3, IL-1F3, IL-1ra3, F630041P17Rik, ICIL-1RA, Intracellular IL 1 receptor antagonist type II, Intracellular interleukin 1 receptor antagonist (icIL 1ra), MGC10430, MVCD4, Type II interleukin 1 receptor antagonist,ATGP3934-10ug,ATGP3934-20ug,ATGP3934-50ug,ATGP3934-100ug,ATGP3934-250ug,ATGP3934-500ug,ATGP3934-1mg,ATGP3934-10,ATGP3934-20,ATGP3934-50,ATGP3934-100,ATGP3934-250,ATGP3934-500,ATGP3934-1

more info or order :

NKMAX product webpage