Recombinant Animal Free Human IL-21 Protein | NKMAX ATGP3927 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant Animal Free Human IL-21 Protein

catalog :

ATGP3927

quantity :

10 ug

price :

176 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant Animal Free Human IL-21 Protein

Domain :

30-162aa

Catalog number (SKU) :

ATGP3927

NCBI :

NP_068575

Description :

IL-21, also known as Interleukin-21, is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumor responses. It has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. It is important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. It is produced by activated T cell, and it influences proliferation of T and B cells and cytolytic activity of natural killer cells. It may be a critical factor in the control of persistent viral infections. It has a potential predicating significance for survival Time in patients in the development of sporadic CRC. It binds to the IL-21R and can activate janus kinase JAK1, JAK3, STAT1, and STAT3 in EDgamma-16 cells. Recombinant human IL-21, was expressed in E. coli and purified by using conventional chromatography techniques. Produced using non-animal reagents in an animal-free laboratory

Alternative Names :

Interleukin-21

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4)

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Gui G., et al. (2017) Clin Immunol. 183:266-272.;; Parrish-Novak J., et al. (2000) Nature. 408(6808):57-63.

Purity :

> 95% by SDS - PAGE

Bioactivity Comment Only :

The activity is determined by the IFN-γ ELISA in a using NK-92 human natural killer cells. The ED50 range ≤ 4 ng/ml.

Applications :

SDS-PAGE, Bioactivity

Gene Category :

Signal Transduction, Hormones & Cytokines

Molecular Weight :

15.5 kDa (134aa) confirmed by MALDI-TOF

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human IL-21 stimulates IFN-γ secretion of the NK-92 human natural killer cells. The ED50 range ≤ 4 ng/ml.

Amino Acid Sequence :

MQGQDRHMIR MRQLIDIVDQ LKNYVNDLVP EFLPAPEDVE TNCEWSAFSC FQKAQLKSAN GNNERIINV SIKKLKRKPP STNAGRRQKH RLTCPSCDSY EKKPPKEFLE RFKSLLQKMI HQHLSSRTHG SEDS

Tag :

Non-Tagged

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

Q9HBE4

Internal Search Terms :

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more info or order :

NKMAX product webpage