Recombinant human RAGE/AGER protein | NKMAX ATGP3923 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human RAGE/AGER protein

catalog :

ATGP3923

quantity :

10 ug

price :

130 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human RAGE/AGER protein

Domain :

24-342aa

Catalog number (SKU) :

ATGP3923

NCBI :

NP_001127

Description :

RAGE, also known as advanced glycosylation end product-specific receptor isoform 1, is a member of the immunoglobulin super-family transmembrane proteins. It mediates interactions of advanced glycosylation end products (AGE). AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. This protein contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. Recombinant human RAGE, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

RAGE, AGER, advanced glycosylation end product-specific receptor isoform 1, SCARJ1, Receptor for advanced glycosylation end products

Concentration :

0.25mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Giurdanella G., et al. (2017) Biochem Pharmacol. 142:145-154;; Zhang L., et al. (2019) Int J Mol Med. 44:885-892

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by the ability of the binding activity in a functional ELISA. The ED50 range ≤15ug/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

61.2 kDa (561aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human HMGB1 is coated at 20 ug/ml (100 ul/well) can bind Human RAGE. The ED50 range ≤15 ug/ml.

Amino Acid Sequence :

QNITARI GEPLVLKCKG APKKPPQRLE WKLNTGRTEA WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI PGKPEIVDSA SELTAGVPNK VGTCVSEGSY PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH PETGLFTLQS ELMVTPARGG DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL VVEPEGGAVA PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LA .

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q15109

Internal Search Terms :

RAGE,ATGP3923-10ug,ATGP3923-20ug,ATGP3923-50ug,ATGP3923-100ug,ATGP3923-250ug,ATGP3923-500ug,ATGP3923-1mg,ATGP3923-10,ATGP3923-20,ATGP3923-50,ATGP3923-100,ATGP3923-250,ATGP3923-500,ATGP3923-1

more info or order :

NKMAX product webpage