Recombinant human IL-6R alpha/IL6R protein | NKMAX ATGP3919 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-6R alpha/IL6R protein

catalog :

ATGP3919

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-6R alpha/IL6R protein

Domain :

20-365aa

Catalog number (SKU) :

ATGP3919

NCBI :

NP_000556

Description :

IL-6R alpha, also known as interleukin-6 receptor subunit alpha isoform 1, is a type I cytokine receptor. It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. It has a modular build of several immunoglobulin-like and fibronectin type III-like domains. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. It is implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Recombinant human IL-6R alpha, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R 1, Membrane glycoprotein 80, gp80, CD126

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Sugita T., et al. (1990) J Exp Med. 171:2001-2009.;;Yamasaki K., et al. (1988) Science. 241:825-828.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its ability to inhibit proliferation using M1 mouse myeloid leukemia cells. The ED50 range ≤20ng/ml with Human IL-6.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Hormones & Cytokines

Additional Comment Only :

ATGP3819 has been replaced with a catalog number ATGP3919.

Molecular Weight :

39.6 kDa (355aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human IL-6 R alpha inhibits Human IL-6 induced cell proliferation in the M1 mouse myeloid leukemia cells. The ED50 range ≤20 ng/ml.

Amino Acid Sequence :

LAPRRCP AQEVARGVLT SLPGDSVTLT CPGVEPEDNA TVHWVLRKPA AGSHPSRWAGMGRRLLLRSV QLHDSGNYSC YRAGRPAGTV HLLVDVPPEE PQLSCFRKSP LSNVVCEWGPRSTPSLTTKA VLLVRKFQNS PAEDFQEPCQ YSQESQKFSC QLAVPEGDSS FYIVSMCVASSVGSKFSKTQ TFQGCGILQP DPPANITVTA VARNPRWLSV TWQDPHSWNS SFYRLRFELRYRAERSKTFT TWMVKDLQHH CVIHDAWSGL RHVVQLRAQE EFGQGEWSEW SPEAMGTPWTESRSPPAENE VSTPMQALTT NKDDDNILFR DSANATSLPV QDSSSVPLP

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P08887

Internal Search Terms :

IL6R a,ATGP3919-10ug,ATGP3919-20ug,ATGP3919-50ug,ATGP3919-100ug,ATGP3919-250ug,ATGP3919-500ug,ATGP3919-1mg,ATGP3919-10,ATGP3919-20,ATGP3919-50,ATGP3919-100,ATGP3919-250,ATGP3919-500,ATGP3919-1

more info or order :

NKMAX product webpage