Recombinant human CTLA4 protein | NKMAX ATGP3914 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CTLA4 protein

catalog :

ATGP3914

quantity :

10 ug

price :

60 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CTLA4 protein

Domain :

36-161aa

Catalog number (SKU) :

ATGP3914

NCBI :

NP_005205

Description :

CTLA-4, also known as cytotoxic T-lymphocyte protein 4, is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. The affinity of CTLA-4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. Recombinant human CTLA-4, fused to hIgG His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CELIAC3, Celiac disease 3, Insulin-dependent diabetes mellitus 12, IDDM12, CD, GSE

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Harper K., et al. (1991) J. Immunol. 147:1037-1044.;; Teft WA., et al. (2006) Annu. Rev. Immunol. 24:65-97.

Purity :

> 95% by SDS-PAGE

Bioactivity Comment Only :

The activity is determined by the IL-2 ELISA in a using Jurkat human acute T cell leukemia cells. The ED50 range ≤150ng/ml with Human B7 1/CD80.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Additional Comment Only :

ATGP3364 has been replaced with a catalog number ATGP3914.

Molecular Weight :

40.8 kDa (368aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human CTLA-4 inhibits Human B7 1/CD80 induced IL-2 secretion of the Jurkat human acute T cell leukemia cells. The ED50 range ≤150 ng/ml.

Amino Acid Sequence :

KAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSD

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P16410

Internal Search Terms :

Cytotoxic T lymphocyte protein 4 isoform CTLA4-TM precursor, Cytotoxic T-lymphocyte-associated antigen 4, CTLA 4, CTLA4, CTLA-4, CD 152, CD152, CELIAC3, CELIAC 3, Celiac disease 3, Insulin-dependent diabetes mellitus 12, Insulin dependent diabetes mellitus 12, IDDM 12, IDDM12, CD, GSE, ATGP3914-10ug, ATGP3914-20ug, ATGP3914-50ug, ATGP3914-100ug, ATGP3914-250ug, ATGP3914-500ug, ATGP3914-1mg, ATGP3914-010, ATGP3914-020, ATGP3914-050, ATGP3914-100, ATGP3914-250, ATGP3914-500, ATGP3914-01M, ATGP3364

more info or order :

NKMAX product webpage