Recombinant human IL-10R alpha/IL10RA protein | NKMAX ATGP3910 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-10R alpha/IL10RA protein

catalog :

ATGP3910

quantity :

10 ug

price :

150 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-10R alpha/IL10RA protein

Domain :

22-235aa

Catalog number (SKU) :

ATGP3910

NCBI :

NP_001549

Description :

IL-10 R alpha, also known as Interleukin-10 receptor subunit alpha, is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. It has been shown to interact with Interleukin 10 and Janus kinase 1. Recombinant human IL-10 R alpha, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin 10 receptor subunit alpha, IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CD210, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1, HIL-10R

Concentration :

0.2mg/ml (determined by Bradford assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Josephson K, et al. (2001) Acta Crystallogr D Biol Crystallogr. 57(Pt 12):1908-11.;;Usacheva A, etal. (2002) J Immunol. 169(3):1302-8.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

Measured by its ability to inhibit proliferation using MC/9 mouse mast cells. The ED50 for this effect is ≤300ng/ml with Human IL-10.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Hormones & Cytokines

Molecular Weight :

25.2 kDa (220aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

Human IL-10 R alpha inhibits Human IL-10 induced cell proliferation in the MC/9 mouse mast cells. The ED50 range is ≤300 ng/ml.

Amino Acid Sequence :

HGTELPSPPS VWFEAEFFHH ILHWTPIPNQ SESTCYEVAL LRYGIESWNS ISNCSQTLSYDLTAVTLDLY HSNGYRARVR AVDGSRHSNW TVTNTRFSVD EVTLTVGSVN LEIHNGFILGKIQLPRPKMA PANDTYESIF SHFREYEIAI RKVPGNFTFT HKKVKHENFS CVQVKPSVAS RSNKGMWSKEECISLTRQYF TVTN

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

His22

Product Type Name :

Recombinant Protein

UniProt No. :

Q13651

Internal Search Terms :

IL10 R a,ATGP3910-10ug,ATGP3910-20ug,ATGP3910-50ug,ATGP3910-100ug,ATGP3910-250ug,ATGP3910-500ug,ATGP3910-1mg,ATGP3910-10,ATGP3910-20,ATGP3910-50,ATGP3910-100,ATGP3910-250,ATGP3910-500,ATGP3910-1

more info or order :

NKMAX product webpage