product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human SPARC protein
catalog :
ATGP3902
quantity :
10 ug
price :
120 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human SPARC protein
Domain :
18-303aa
Catalog number (SKU) :
ATGP3902
NCBI :
NP_003109
Description :
SPARC, also known as osteonectin, is a member of secreted matricellular proteins. It is produced by fibroblasts, capillary endothelial cells, platelets and macrophages, especially in areas of tissue morphogenesis and remodeling. This protein regulates cell growth through interactions with the extracellular matrix and cytokines and binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. It functions as modulating cell-cell and cell-matrix interactions and its de-adhesive and growth inhibitory properties in non-transformed cell. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. A correlation between SPARC over-expression and ampullary cancers and chronic pancreatitis has been found. It also shows affinity for collagen in addition to bone mineral calcium. Recent studies have also demonstrated a role for SPARC in sensitizing therapy-resistant cancers. Notably, it is linked to human obesity. Recombinant human SPARC, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Alternative Names :
SPARC, Basement-membrane protein 40, BM-40, Osteonectin, ON, Secreted protein acidic and rich in cysteine, OI17
Concentration :
0.5mg/ml (determined by absorbance at 280nm)
Formulation :
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
McDonald LT., et al. (2018) Am J Physiol Heart Circ Physiol. 315(1):H92-H100.;; Wang B., et al. (2018) J Biol Regul Homeost Agents. 32:1525-1531.
Purity :
> 90% by SDS-PAGE
Applications :
SDS-PAGE
Antigen Species :
Human
Gene Category :
Cell Cycle
Molecular Weight :
33.8 kDa (295aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Amino Acid Sequence :
APQQEAL PDETEVVEET VAEVTEVSVG ANPVQVEVGE FDDGAEETEE EVVAENPCQN HHCKHGKVCE LDENNTPMCV CQDPTSCPAP IGEFEKVCSN DNKTFDSSCH FFATKCTLEG TKKGHKLHLD YIGPCKYIPP CLDSELTEFP LRMRDWLKNV LVTLYERDED NNLLTEKQKL RVKKIHENEK RLEAGDHPVE LLARDFEKNY NMYIFPVHWQ FGQLDQHPID GYLSHTELAP LRAPLIPMEH CTTRFFETCD LDNDKYIALD EWAGCFGIKQ KDIDKDLVI
Tag :
His-Tag
Expression System :
Baculovirus
Predicted nterm :
Ala
Product Type Name :
Recombinant Protein
UniProt No. :
P09486
Internal Search Terms :
SPARC,ATGP3902-10ug,ATGP3902-20ug,ATGP3902-50ug,ATGP3902-100ug,ATGP3902-250ug,ATGP3902-500ug,ATGP3902-1mg,ATGP3902-10,ATGP3902-20,ATGP3902-50,ATGP3902-100,ATGP3902-250,ATGP3902-500,ATGP3902-1
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.