Recombinant human FGF R2 beta (lllb) protein | NKMAX ATGP3899 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human FGF R2 beta (lllb) protein

catalog :

ATGP3899

quantity :

10 ug

price :

140 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human FGF R2 beta (lllb) protein

Domain :

22-289aa

Catalog number (SKU) :

ATGP3899

NCBI :

NP_001138391

Description :

FGF R2 beta (lllb), also known as fibroblast growth factor receptor 2 isoform 9, is a member of the fibroblast growth factor receptor family. This protein has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. On a molecular level these signals mediate cell division, growth and differentiation. Also, it is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Mutations in FGF R2 beta are associated with numerous medical conditions that include abnormal bone development (e.g. craniosynostosis syndromes: Apert syndrome, Antley-Bixler syndrome, Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome) and cancer. (e.g. Breast cancer, endometrial cancer and melanoma) Recombinant Human FGF R2 beta (lllb), fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

FGF R2 beta, FGF R2b, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, Fibroblast growth factor receptor 2, FGFR-2, K-sam ,Keratinocyte growth factor receptor

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Galzie Z., et al. (1997) Biochem. Cell Biol. 75:669-685.;;Ornitz DM., et al, (1996) J Biol Chem. 271:15292-15297.

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Growth factors

Molecular Weight :

56.8 kDa (507aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

RPSFSLVEDT TLEPEDAISS GDDEDDTDGA EDFVSENSNN KRAPYWTNTE KMEKRLHAVP AANTVKFRCP AGGNPMPTMR WLKNGKEFKQ EHRIGGYKVR NQHWSLIMES VVPSDKGNYT CVVENEYGSI NHTYHLDVVE RSPHRPILQA GLPANASTVV GGDVEFVCKV YSDAQPHIQW IKHVEKNGSK YGPDGLPYLK VLKHSGINSS NAEVLALFNV TEADAGEYIC KVSNYIGQAN QSAWLTVLPK QQAPGREKEI TASPDYLE

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Arg22

Product Type Name :

Recombinant Protein

UniProt No. :

P21802

Internal Search Terms :

FGF R2 b (lllb),ATGP3899-10ug,ATGP3899-20ug,ATGP3899-50ug,ATGP3899-100ug,ATGP3899-250ug,ATGP3899-500ug,ATGP3899-1mg,ATGP3899-10,ATGP3899-20,ATGP3899-50,ATGP3899-100,ATGP3899-250,ATGP3899-500,ATGP3899-1

more info or order :

NKMAX product webpage