Recombinant mouse HGFR/c-MET protein | NKMAX ATGP3896 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant mouse HGFR/c-MET protein

catalog :

ATGP3896

quantity :

10 ug

price :

110 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant mouse HGFR/c-MET protein

Domain :

25-931aa

Catalog number (SKU) :

ATGP3896

NCBI :

NP_032617

Description :

HGFR, also known as c-Met, is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. It regulates many physiological processes including proliferation, scattering, morphogenesis and survival. This ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. This protein interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. Recombinant mouse HGF R/c-MET, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Tyrosine-protein kinase Met, SF receptor, Scatter factor receptor, RCCP2, Proto-oncogene c-Met, Par4, MET proto-oncogene receptor tyrosine kinase, Met, HGFR, HGF/SF receptor, HGF receptor, HGF R/c-MET, HGF, Hepatocyte growth factor receptor, c-Met, AI838057

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Kim JH., et al. (2018) J Cancer. 9:3427-3434.;; Chen RL., et al. (2019) BMC Cancer. 18:1171.

Purity :

> 85% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Mouse

Gene Category :

Signal Transduction

Molecular Weight :

127.8 kDa (1146aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

ECKEALVKSE MNVNMKYQLP NFTAETPIQN VVLHGHHIYL GATNYIYVLN DKDLQKVSEF KTGPVLEHPD CLPCRDCSSK ANSSGGVWKD NINMALLVDT YYDDQLISCG SVNRGTCQRH VLPPDNSADI QSEVHCMFSP EEESGQCPDC VVSALGAKVL LSEKDRFINF FVGNTINSSY PPGYSLHSIS VRRLKETQDG FKFLTDQSYI DVLPEFQDSY PIKYIHAFES NHFIYFLTVQ KETLDAQTFH TRIIRFCSVD SGLHSYMEMP LECILTEKRR KRSTREEVFN ILQAAYVSKP GANLAKQIGA SPSDDILFGV FAQSKPDSAE PVNRSAVCAF PIKYVNDFFN KIVNKNNVRC LQHFYGPNHE HCFNRTLLRN SSGCEARSDE YRTEFTTALQ RVDLFMGRLN QVLLTSISTF IKGDLTIANL GTSEGRFMQV VLSRTAHLTP HVNFLLDSHP VSPEVIVEHP SNQNGYTLVV TGKKITKIPL NGLGCGHFQS CSQCLSAPYF IQCGWCHNQC VRFDECPSGT WTQEICLPAV YKVFPTSAPL EGGTVLTICG WDFGFRKNNK FDLRKTKVLL GNESCTLTLS ESTTNTLKCT VGPAMSEHFN VSVIISNSRE TTQYSAFSYV DPVITSISPR YGPQAGGTLL TLTGKYLNSG NSRHISIGGK TCTLKSVSDS ILECYTPAQT TSDEFPVKLK IDLANRETSS FSYREDPVVY EIHPTKSFIS GGSTITGIGK TLNSVSLPKL VIDVHEVGVN YTVACQHRSN SEIICCTTPS LKQLGLQLPL KTKAFFLLDG ILSKHFDLTY VHNPVFEPFE KPVMISIGNE NVVEIKGNNI DPEAVKGEVL KVGNQSCESL HWHSGAVLCT VPSDLLKLNS ELNIEWKQAV SSTVLGKVIV QPDQNFA

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Glu25

Product Type Name :

Recombinant Protein

UniProt No. :

P16056

Internal Search Terms :

HGF c-MET, ATGP3896-10ug,ATGP3896-20ug,ATGP3896-50ug,ATGP3896-100ug,ATGP3896-250ug,ATGP3896-500ug,ATGP3896-1mg, ATGP3896-10,ATGP3896-20,ATGP3896-50,ATGP3896-100,ATGP3896-250,ATGP3896-500,ATGP3896-1,ATGP3896-10ug,ATGP3896-20ug,ATGP3896-50ug,ATGP3896-100ug,ATGP3896-250ug,ATGP3896-500ug,ATGP3896-1mg,ATGP3896-10,ATGP3896-20,ATGP3896-50,ATGP3896-100,ATGP3896-250,ATGP3896-500,ATGP3896-1

more info or order :

NKMAX product webpage