Recombinant human CD72 protein | NKMAX ATGP3869 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CD72 protein

catalog :

ATGP3869

quantity :

10 ug

price :

120 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CD72 protein

Domain :

117-359aa

Catalog number (SKU) :

ATGP3869

NCBI :

NP_001773

Description :

CD72, also known as B-cell differentiation antigen CD72, is a type II transmembrane glycoprotein carrying a C-type lectin domain. It plays a role in immune system regulation of animals and expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells as a homodimer. Also, this protein associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulation and dampens BCR signaling through interactions with the phosphatase SHP1. It binding to Semaphorin 4D induces cytokine production by monocytes and dendritic cells, inhibits SCF R/ckit induced mast cell proliferation and activation, and inhibits the cytolytic activity of NK cells. Moreover, BCR signaling enhances phosphorylation of CD72 and its recruitment of SHP-1. Recombinant human CD72, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

CD72, CD72b, LYB2, B-cell differentiation antigen CD72, Lyb-2, CD_antigen: CD72

Concentration :

0.5mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. 50mM Tris-HCl buffer (pH 6.8) containing 2mM DTT, 0.2M NaCl, 50% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Vadasz Z., et al, (2014) Semin. Arthritis Rheum. 43:767-771.;;Adachi T., et al, (1998) J. Immunol. 160:4662-4665.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

55.3 kDa (485aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

RYLQVSQ QLQQTNRVLE VTNSSLRQQL RLKITQLGQS AEDLQGSRRE LAQSQEALQV EQRAHQAAEG QLQACQADRQ KTKETLQSEE QQRRALEQKL SNMENRLKPF FTCGSADTCC PSGWIMHQKS CFYISLTSKN WQESQKQCET LSSKLATFSE IYPQSHSYYF LNSLLPNGGS GNSYWTGLSS NKDWKLTDDT QRTRTYAQSS KCNKVHKTWS WWTLESESCR SSLPYICEMT AFRFPD .

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P21854

Internal Search Terms :

CD72,ATGP3869-10ug,ATGP3869-20ug,ATGP3869-50ug,ATGP3869-100ug,ATGP3869-250ug,ATGP3869-500ug,ATGP3869-1mg,ATGP3869-10,ATGP3869-20,ATGP3869-50,ATGP3869-100,ATGP3869-250,ATGP3869-500,ATGP3869-1

more info or order :

NKMAX product webpage