protein

Recombinant human Cathepsin Z protein

ATGP3848

10 ug

180 USD

Recombinant human Cathepsin Z protein

24-303aa

ATGP3848

NP_001327

Cathepsin Z, also known Cathepsin X and Cathepsin P, is a member of the C1 family of lysosomal cysteine proteases. It exhibits carboxy-monopeptidase and carboxy-dipeptidase activity. This protein regulates maturation of dendritic cells and plays important role in the initiation of adaptive immunity. It is also involved in tumor and immune cells as higher expression is found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa. Recombinant human Cathepsin Z protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Carboxypeptidase LB, Cathepsin B2, Cathepsin IV, Cathepsin P, Cathepsin X, Cathepsin Y, Cathepsin Z, Cathepsin Z preproprotein, Cathepsin Z1, CatX, CTSP, CTSX, CTSZ, Cysteine-type carboxypeptidase, Lysosomal carboxypeptidase B

0.5mg/ml (determined by absorbance at 280nm)

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Akkari L., et al, (2014) Genes Dev. 28:2134-2150.;;Allan ERO., et al, (2017) J Neuroinflammation. 14:103.

> 95% by SDS-PAGE

Specific activity is > 1,400pmol/min/ug in which one unit will convert 1.0pmole of Mca-PLGL-Dpa-AR-NH2 to MCA- Pro-Leu-OH per minute at pH 3.5 at 25C.

SDS-PAGE, Enzyme Activity

Human

Cancer

32.5 kDa (288aa)

< 1 EU per 1ug of protein (determined by LAL method)

Specific activity is > 1,400 pmol/min/ug in which one unit will convert 1.0 pmole of Mca-PLGL-Dpa-AR-NH2 to MCA- Pro-Leu-OH per minute at pH 3.5 at 25C.

GLYFRRGQTC YRPLRGDGLA PLGRSTYPRP HEYLSPADLP KSWDWRNVDG VNYASITRNQ HIPQYCGSCW AHASTSAMAD RINIKRKGAW PSTLLSVQNV IDCGNAGSCE GGNDLSVWDY AHQHGIPDET CNNYQAKDQE CDKFNQCGTC NEFKECHAIR NYTLWRVGDY GSLSGREKMM AEIYANGPIS CGIMATERLA NYTGGIYAEY QDTTYINHVV SVAGWGISDG TEYWIVRNSW GEPWGERGWL RIVTSTYKDG KGARYNLAIE EHCTFGDPIV LEHHHHHH

His-Tag

Baculovirus

Gly24

Recombinant Protein

Q9UBR2

Carboxypeptidase LB, Cathepsin B2, Cathepsin IV, Cathepsin P, Cathepsin X, Cathepsin X Z P, Cathepsin X,Z,P, Cathepsin X/Z/P, Cathepsin XZP, Cathepsin Y, Cathepsin Z, Cathepsin Z preproprotein, Cathepsin Z1, Cathepsin-IV, Cathepsin-X, Cathepsin-Y, Cathepsin-Z, Cathepsin-Z1, Cathepsin-B2, CatX, CTSP, CTSX, CTSZ, Cysteine-type carboxypeptidase, Lysosomal carboxypeptidase B, ATGP3848-10ug, ATGP3848-20ug, ATGP3848-50ug, ATGP3848-100ug, ATGP3848-250ug, ATGP3848-500ug, ATGP3848-1mg, ATGP3848-010, ATGP3848-020, ATGP3848-050, ATGP3848-100, ATGP3848-250, ATGP3848-500, ATGP3848-01M