Recombinant human IL-22 protein | NKMAX ATGP3842 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-22 protein

catalog :

ATGP3842

quantity :

10 ug

price :

240 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-22 protein

Domain :

34-179aa

Catalog number (SKU) :

ATGP3842

NCBI :

NP_065386

Description :

IL22, also known as interleukin-22, is a member of a group of cytokines involved the IL-10 family or IL-10 subfamily. This protein shares us of IL-10R2 in cell signaling with other members of this family, IL-10, IL-26, IL-28A/B and IL-29. It is produced by normal T cells upon anti-CD3 stimulation and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. Also, it can be produced by Th17 cells and play a role in the coordinated response of both adaptive and innate immune systems. Biological activity of IL-22 is the functional receptor complex consists of two receptor subunits, IL-22R and IL-10R and is further regulated by interactions with a soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1. Recombinant human IL22, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-22, IL22, IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFa, TIFIL-23, zcyto18, Macrophagleukin-22, IL22, 2

Concentration :

1mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Kontenko SV., et al, (2001) J. Biol. Chem. 276:2725-2732.;;Xie MH., et al, (2000) J. Biol. Chem. 275:31335-31339.

Purity :

> 90% by SDS-PAGE

Bioactivity Comment Only :

The activity is determined by the IL-10 ELISA in a using COLO 205 human colorectal adenocarcinoma cells. The ED50 range ≤1.2ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Hormones & Cytokines

Molecular Weight :

17.8 kDa (155aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

The activity is determined by the IL-10 ELISA in a using COLO 205 human colorectal adenocarcinoma cells. The ED50 range ≤1.2 ng/ml.

Amino Acid Sequence :

APISSHC RLDKSNFQQP YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD TVKKLGESGE IKAIGELDLL FMSLRNACI

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q9GZX6

Internal Search Terms :

IL22, Interleukin-22, IL22, IL-21, IL-22, IL-D110, IL-TIF, ILTIF, TIFa, TIFIL-23, zcyto18,ATGP3842-10ug,ATGP3842-20ug,ATGP3842-50ug,ATGP3842-100ug,ATGP3842-250ug,ATGP3842-500ug,ATGP3842-1mg,ATGP3842-10,ATGP3842-20,ATGP3842-50,ATGP3842-100,ATGP3842-250,ATGP3842-500,ATGP3842-1

more info or order :

NKMAX product webpage