Recombinant human CNTFR alpha protein | NKMAX ATGP3830 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human CNTFR alpha protein

catalog :

ATGP3830

quantity :

10 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human CNTFR alpha protein

Domain :

23-342aa

Catalog number (SKU) :

ATGP3830

NCBI :

NP_001833

Description :

CNTFR, also known as ciliary neurotrophic factor receptor subunit alpha preproprotein, is expressed in glial cells within the central and peripheral nervous systems. It stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types such as sensory, sympathetic, ciliary and motor neurons. This protein has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6. Also, it possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage. It activates downstream signaling molecules such as STAT-3 in areas of the hypothalamus which regulate food intake. Recombinant human CNTFR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques

Alternative Names :

Ciliary neurotrophic factor receptor subunit alpha, CNTFR, CNTFR-alpha, ciliary neurotrophic factor receptor

Concentration :

1mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Davis S., et al. (1991) Science. 253:59-63.;;Sleeman MW., et al. (2000) Pharm Acta Helv. 74:265-272

Purity :

> 95% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Neuroscience

Molecular Weight :

36.9 kDa (329aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

ADPQRHSPQE APHVQYERLG SDVTLPCGTA NWDAAVTWRV NGTDLAPDLL NGSQLVLHGL ELGHSGLYAC FHRDSWHLRH QVLLHVGLPP REPVLSCRSN TYPKGFYCSW HLPTPTYIPN TFNVTVLHGS KIMVCEKDPA LKNRCHIRYM HLFSTIKYKV SISVSNALGH NATAITFDEF TIVKPDPPEN VVARPVPSNP RRLEVTWQTP STWPDPESFP LKFFLRYRPL ILDQWQHVEL SDGTAHTITD AYAGKEYIIQ VAAKDNEIGT WSDWSVAAHA TPWTEEPRHL TTEAQAAETT TSTTSSLAPP PTTKICDPGE LGSHHHHHH

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P26992

Internal Search Terms :

CNTF R a, Ciliary neurotrophic factor receptor subunit alpha, CNTFR, CNTFR-alpha, ciliary neurotrophic factor receptor,ATGP3830-10ug,ATGP3830-20ug,ATGP3830-50ug,ATGP3830-100ug,ATGP3830-250ug,ATGP3830-500ug,ATGP3830-1mg,ATGP3830-10,ATGP3830-20,ATGP3830-50,ATGP3830-100,ATGP3830-250,ATGP3830-500,ATGP3830-1

more info or order :

NKMAX product webpage