Recombinant human Endocan/ESM1 protein | NKMAX ATGP3827 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Endocan/ESM1 protein

catalog :

ATGP3827

quantity :

10 ug

price :

240 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Endocan/ESM1 protein

Domain :

20-184aa

Catalog number (SKU) :

ATGP3827

NCBI :

NP_008967

Description :

ESM1, also known as endothelial cell-specific molecule 1 isoform a, is a secreted cysteine-rich dermatan sulfate proteoglycan. This protein primarily expressed by endothelial cells within the vascular capillary network in the alveolar walls of the lung and also at lower level in kidney. The expression of it is upregulated by TNF-alpha, IL-beta or lipopolysaccharide and down-regulated by IFN-gamma. It plays roles on angiogenesis, sprouting, and may have potent implications in lung endothelial cell-leukocyte interaction. Also, this protein has dermatan sulfate (DS) that is covalently attached to serine 137. It binds using DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing ESM1 has been shown to induce tumor formation, suggesting that it may be involved in the pathophysiology of tumor growth in vivo. Recombinant human ESM1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Endocan, Endothelial cell-specific molecule 1, Endothelial cell-specific molecule 1 isoform a, ESM1

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Bechard D., et al, (2001) J. Biol. Chem. 276:48341-48349.;;Scherpereel A., et al. (2003) Cancer Res. 63:6084

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cancer

Molecular Weight :

19.2 kDa (174aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

ADLWSNNYAV DCPQHCDSSE CKSSPRCKRT VLDDCGCCRV CAAGRGETCY RTVSGMDGMK CGPGLRCQPS NGEDPFGEEF GICKDCPYGT FGMDCRETCN CQSGICDRGT GKCLKFPFFQ YSVTKSSNRF VSLTEHDMAS GDGNIVREEV VKENAAGSPV MRKWLNPRHH HHHH

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q9NQ30

Internal Search Terms :

Endocan, Endothelial cell-specific molecule 1, Endothelial cell-specific molecule 1 isoform a, ESM1, ATGP3827-10ug, ATGP3827-20ug, ATGP3827-50ug, ATGP3827-100ug, ATGP3827-250ug, ATGP3827-500ug, ATGP3827-1mg, ATGP3827-010, ATGP3827-020, ATGP3827-050, ATGP3827-100, ATGP3827-250, ATGP3827-500, ATGP3827-01M

more info or order :

NKMAX product webpage