Recombinant human Haptoglobin/HP protein | NKMAX ATGP3824 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human Haptoglobin/HP protein

catalog :

ATGP3824

quantity :

10 ug

price :

105 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human Haptoglobin/HP protein

Domain :

19-347aa

Catalog number (SKU) :

ATGP3824

NCBI :

NP_001119574

Description :

HP, also known as haptoglobin isoform 2, is consists of two alpha and two beta chains, connected by disulfide bridges in its simplest form. The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis. In blood plasma, this protein binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). It functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. For this reason, it is often referred to as the suicide protein. Recombinant human HP, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Haptoglobin isoform 2 preproprotein, Zonulin, BP, HP2ALPHA2, HPA1S

Concentration :

0.25mg/ml (determined by BCA assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Kurosky,A., et al, (1980) Proc. Natl. Acad. Sci. U.S.A. 77:3388-3392.;;Ofon E., et al, (2017) PLoS Negl Trop Dis 11:e0005979.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Cardiovascular

Molecular Weight :

37.7 kDa (338aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

VDSGNDV TDIADDGCPK PPEIAHGYVE HSVRYQCKNY YKLRTEGDGV YTLNNEKQWI NKAVGDKLPE CEAVCGKPKN PANPVQRILG GHLDAKGSFP WQAKMVSHHN LTTGATLINE QWLLTTAKNL FLNHSENATA KDIAPTLTLY VGKKQLVEIE KVVLHPNYSQ VDIGLIKLKQ KVSVNERVMP ICLPSKDYAE VGRVGYVSGW GRNANFKFTD HLKYVMLPVA DQDQCIRHYE GSTVPEKKTP KSPVGVQPIL NEHTFCAGMS KYQEDTCYGD AGSAFAVHDL EEDTWYATGI LSFDKSCAVA EYGVYVKVTS IQDWVQKTIA EN

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

P00738

Internal Search Terms :

HP, Haptoglobin isoform 2, HP, BP, HP2ALPHA2, HPA1S,ATGP3824-10ug,ATGP3824-20ug,ATGP3824-50ug,ATGP3824-100ug,ATGP3824-250ug,ATGP3824-500ug,ATGP3824-1mg,ATGP3824-10,ATGP3824-20,ATGP3824-50,ATGP3824-100,ATGP3824-250,ATGP3824-500,ATGP3824-1

more info or order :

NKMAX product webpage