Recombinant human MDL-1/CLEC5A protein | NKMAX ATGP3820 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human MDL-1/CLEC5A protein

catalog :

ATGP3820

quantity :

10 ug

price :

240 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human MDL-1/CLEC5A protein

Domain :

28-188aa

Catalog number (SKU) :

ATGP3820

NCBI :

NP_037384

Description :

CLEC5A, also known as C-type lectin domain family 5 member A isoform 1, is a member of the CTL/CTLD superfamily that have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. It functions as a cell attachment receptor for all four serotypes of Dengue virus as well as Japanese encephalitis virus. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release. This protein acts as a positive regulator of osteoclastogenesis and a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Recombinant human CLEC5A protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

C-type lectin domain family 5 member A, C-type lectin domain family 5 member A isoform 1, CLEC5A, CLECSF5, MDL-1, MDL1, Macroprhage lectin 2

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Gonzalez-Dominguez E., et al, (2015) J Leukoc Biol. 98:453-466.;;Chen ST., et al, (2017) Nat Commun. 8:299

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

19.5 kDa (170aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

ADLPQIFNKS NDGFTTTRSY GTVSQIFGSS SPSPNGFITT RSYGTVCPKD WEFYQARCFF LSTSESSWNE SRDFCKGKGS TLAIVNTPEK LKFLQDITDA EKYFIGLIYH REEKRWRWIN NSVFNGNVTN QNQNFNCATI GLTKTFDAAS CDISYRRICE KNAKHHHHHH

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q9NY25

Internal Search Terms :

CLEC5A, CLECSF5, C-type lectin domain family 5 member A, C-type lectin domain family 5 member A isoform 1, Kidney associated DCDC2 antisense RNA 1, Macroprhage lectin 2, MDL1, MDL-1, RU2, RU2 antisense gene protein, Ru2AS, ATGP3820-10ug, ATGP3820-20ug, ATGP3820-50ug, ATGP3820-100ug, ATGP3820-250ug, ATGP3820-500ug, ATGP3820-1mg, ATGP3820-010, ATGP3820-020, ATGP3820-050, ATGP3820-100, ATGP3820-250, ATGP3820-500, ATGP3820-01M

more info or order :

NKMAX product webpage