product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human KMT5A protein
catalog :
ATGP3812
quantity :
10 ug
price :
80 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human KMT5A protein
Domain :
195-352aa
Catalog number (SKU) :
ATGP3812
NCBI :
NP_065115
Description :
KMT5A, also known as N-lysine methyltransferase KMT5A isoform 1, is an enzyme which catalyzes mono-methylation of histone H4 at lysine 20 (H4K20me1). It is implicated in cell-cycle-dependent transcriptional silencing and mitotic regulation in metazoans. It acts as a barrier to prevent cellular senescence through chromatin-mediated regulation of senescence-associated metabolic remodeling. It mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. The loss of KMT5A concurrently stimulate nucleolar function and retinoblastoma protein-mediated mitochondrial metabolism. Recombinant human KMT5A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Alternative Names :
N-lysine methyltransferase KMT5A isoform 1, KMT5A, PR-Set7, SET07, SET8, SETD8
Concentration :
0.25mg/ml (determined by absorbance at 280nm)
Formulation :
Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 0.2M NaCl, 1mM EDTA, 50% glycerol
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Nishioka K., et al. (2002) Mol Cell. 9:1201-1213.;;Tanaka H., et al. (2017) Cell Rep. 18:2148-2161.
Purity :
> 85% by SDS-PAGE
Applications :
SDS-PAGE
Antigen Species :
Human
Gene Category :
Epigenomics (Transcription & Translation)
Molecular Weight :
18.9 kDa (165aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Amino Acid Sequence :
MKAELQSEER KRIDELIESG KEEGMKIDLI DGKGRGVIAT KQFSRGDFVV EYHGDLIEIT DAKKREALYA QDPSTGCYMY YFQYLSKTYC VDATRETNRL GRLINHSKCG NCQTKLHDID GVPHLILIAS RDIAAGEELL YDYGDRSKAS IEAHPWLKHH HHHHH
Tag :
His-Tag
Expression System :
Baculovirus
Predicted nterm :
Met
Product Type Name :
Recombinant Protein
UniProt No. :
Q9NQR1
Internal Search Terms :
KMT5A, N-lysine methyltransferase KMT5A isoform 1, KMT5A, PR-Set7, SET07, SET8, SETD8,ATGP3812-10ug,ATGP3812-20ug,ATGP3812-50ug,ATGP3812-100ug,ATGP3812-250ug,ATGP3812-500ug,ATGP3812-1mg,ATGP3812-10,ATGP3812-20,ATGP3812-50,ATGP3812-100,ATGP3812-250,ATGP3812-500,ATGP3812-1
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.