Recombinant human IL-21 protein | NKMAX ATGP3802 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human IL-21 protein

catalog :

ATGP3802

quantity :

10 ug

price :

150 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human IL-21 protein

Domain :

30-162aa

Catalog number (SKU) :

ATGP3802

NCBI :

NP_068575

Description :

IL21, also known as interleukin-21 isoform 1, is a T-helper cytokine that regulates humoral immunity and cell-mediated anti-tumour responses. It has broad immunoregulatory activity and can modulate both humoral and cell-mediated responses. It is important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. It is produced by activated T cells, and it influences proliferation of T and B cells and cytolytic activity of natural killer cells. It may be a critical factor in the control of persistent viral infections. It has a potential predicating significance for survival time in patients in the development of sporadic CRC. It binds to the IL-21R and can activate Janus kinase JAK1, JAK3, STAT1, and STAT3 in EDgamma-16 cells. Recombinant human IL21, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Interleukin-21 isoform 1, IL21, CVID11, IL-21, Za11

Concentration :

0.25mg/ml (determined by Bradford assay)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Parrish-Novak J., et al. (2000) Nature. 408:57-63.;;Cui G., et al. (2017) Clin Immunol. 183:266-272.

Purity :

> 85% by SDS-PAGE

Bioactivity Comment Only :

The activity is determined by the IFN-g ELISA in a using NK-92 cell. The ED50 range ≤ 10ng/ml.

Applications :

SDS-PAGE, Bioactivity

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

16.9 kDa (145aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Bioactivity Comment and Pics :

The activity is determined by the IFN-g ELISA in a using NK-92 cell. The ED50 range ≤ 10 ng/ml.

Amino Acid Sequence :

QGQD RHMIRMRQLI DIVDQLKNYV NDLVPEFLPA PEDVETNCEW SAFSCFQKAQ LKSANTGNNE RIINVSIKKL KRKPPSTNAG RRQKHRLTCP SCDSYEKKPP KEFLERFKSL LQKMIHQHLS SRTHGSEDS

Tag :

His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q9HBE4

Internal Search Terms :

IL21, Interleukin-21 isoform 1, IL21, CVID11, IL-21, Za11,ATGP3802-10ug,ATGP3802-20ug,ATGP3802-50ug,ATGP3802-100ug,ATGP3802-250ug,ATGP3802-500ug,ATGP3802-1mg,ATGP3802-10,ATGP3802-20,ATGP3802-50,ATGP3802-100,ATGP3802-250,ATGP3802-500,ATGP3802-1

more info or order :

NKMAX product webpage