product summary
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company name :
NKMAX
product type :
protein
product name :
Recombinant human NFATC2 protein
catalog :
ATGP3772
quantity :
4 ug
price :
80 USD
more info or order :
product information
Product Type :
Proteins
Item Name :
Recombinant human NFATC2 protein
Domain :
396-678aa
Catalog number (SKU) :
ATGP3772
NCBI :
NP_775114
Description :
NFATC2, also known as nuclear factor of activated T-cells cytoplasmic 2 isoform C, is a member of the nuclear factor of activated T cells family. This protein plays a vital role in the course of T helper cell activation, differentiation, and effector function. Although KO of an individual NFAT isoform in T cells leads to rather mild effects, T cells deficient for NFATC1 and 2 completely fail to produce T helper cell effector cytokines, such as the interleukins IL-2 and IL-4 or interferon gamma. Also, it is highly phosphorylated and retained in the cytoplasm. Following T cell receptor (TCR) stimulation, dephosphorylation by calcium-activated calcineurin induces a conformational change of NFATC2 that exposes one or more nuclear localization sequences. Recombinant human NFATC2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Alternative Names :
Nuclear factor of activated T-cells cytoplasmic 2 isoform C, NFATC2, NFAT1, NFATP
Concentration :
0.25mg/ml (determined by absorbance at 280nm)
Formulation :
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 40% glycerol, 1mM DTT
Storage :
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
General References :
Gabriel CH., et al, (2016) J. Biol. Chem. 291:24172-24187.;;Ho S., et al, (1994) Adv. Exp. Med. Biol. 365:167-173.
Purity :
> 90% by SDS-PAGE
Applications :
SDS-PAGE
Antigen Species :
Human
Gene Category :
Signal Transduction
Molecular Weight :
33.1 kDa (290aa)
Endotoxin :
< 1 EU per 1ug of protein (determined by LAL method)
Amino Acid Sequence :
PLEWPLSSQS GSYELRIEVQ PKPHHRAHYE TEGSRGAVKA PTGGHPVVQL HGYMENKPLG LQIFIGTADE RILKPHAFYQ VHRITGKTVT TTSYEKIVGN TKVLEIPLEP KNNMRATIDC AGILKLRNAD IELRKGETDI GRKNTRVRLV FRVHIPESSG RIVSLQTASN PIECSQRSAH ELPMVERQDT DSCLVYGGQQ MILTGQNFTS ESKVVFTEKT TDGQQIWEME ATVDKDKSQP NMLFVEIPEY RNKHIRTPVK VNFYVINGKR KRSQPQHFTY HPV
Tag :
His-Tag
Expression System :
Baculovirus
Predicted nterm :
Pro396
Product Type Name :
Recombinant Protein
UniProt No. :
Q13469
Internal Search Terms :
NFATC2, Nuclear factor of activated T-cells cytoplasmic 2 isoform C, NFATC2, NFAT1, NFATP,ATGP3772-10ug,ATGP3772-20ug,ATGP3772-50ug,ATGP3772-100ug,ATGP3772-250ug,ATGP3772-500ug,ATGP3772-1mg,ATGP3772-10,ATGP3772-20,ATGP3772-50,ATGP3772-100,ATGP3772-250,ATGP3772-500,ATGP3772-1
more info or order :
company information
NKMAX
SNUH Health Care Innovation Park 6F
172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
https://www.nkmaxbio.com172 Dolma-ro, Bundang-gu
Seongnam-si, Gyeonggi-do
82-31-8017-8114
headquarters: South Korea
NKMAX Co. Ltd. is a biotech company that manufactures and supplies a unique line of quality proteins and antibodies worldwide to both researchers and retailers.