Recombinant human ICOS protein | NKMAX ATGP3771 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human ICOS protein

catalog :

ATGP3771

quantity :

4 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human ICOS protein

Domain :

21-140aa

Catalog number (SKU) :

ATGP3771

NCBI :

NP_036224

Description :

ICOS, also known as inducible T-cell costimulator, is a member of the CD28 family of immune-assisted stimulatory receptors. The interaction of B7-H2 / ICOS plays a crucial role in Th cell differentiation, T-B cell interaction and humoral immune response essential for the formation of reproductive centers and the production of cytokine IL-4. In addition, this protein is more potent in inducing IL-10 production, a cytokine important for the inhibitory function of T regulatory cells. The B7-1 / B7-2-CD28 / CTLA-4 and ICOS-B7RP-1 pathways provide an important second signal that can regulate the activation, inhibition and fine regulation of T-lymphocyte responses. It stimulates production of Th1 and Th2 cytokines, but may play a role in the generation of Th2 cells. Recombinant human ICOS, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Alternative Names :

Inducible T-cell costimulator, ICOS, AILIM, CD278, CVID1

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. 20mM MES buffer (pH 5.5) containing 40% glycerol, 2mM DTT, 1mM EDTA 0.1M NaCl

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Gonzalo, J.A., et al. (2001) J. Immunol. 166:1-5.;;Tezukak., et al. (2000) Biochem Biophys Res Commun. 276:335-345

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

40.8 kDa (362aa)

Endotoxin :

< 1 EU per 1ug of protein (determined by LAL method)

Amino Acid Sequence :

EINGSAN YEMFIFHNGG VQILCKYPDI VQQFKMQLLK GGQILCDLTK TKGSGNTVSI KSLKFCHSQL SNNSVSFFLY NLDHSHANYY FCNLSIFDPP PFKVTLTGGY LHIYESQLCC QLK

Tag :

hIgG-His-Tag

Expression System :

Baculovirus

Predicted nterm :

Ala

Product Type Name :

Recombinant Protein

UniProt No. :

Q9Y6W8

Internal Search Terms :

ICOS, Inducible T-cell costimulator, ICOS, AILIM, CD278, CVID1,ATGP3771-10ug,ATGP3771-20ug,ATGP3771-50ug,ATGP3771-100ug,ATGP3771-250ug,ATGP3771-500ug,ATGP3771-1mg,ATGP3771-10,ATGP3771-20,ATGP3771-50,ATGP3771-100,ATGP3771-250,ATGP3771-500,ATGP3771-1

more info or order :

NKMAX product webpage