Recombinant human HLA-G protein | NKMAX ATGP3743 product information

product summary

company name :

NKMAX

product type :

protein

product name :

Recombinant human HLA-G protein

catalog :

ATGP3743

quantity :

4 ug

price :

80 USD

more info or order :

NKMAX product webpage

product information

Product Type :

Proteins

Item Name :

Recombinant human HLA-G protein

Domain :

25-308aa

Catalog number (SKU) :

ATGP3743

NCBI :

NP_002118.1

Description :

HLA-G, also known as HLA class I histocompatibility antigen, alpha chain G, belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. HLA-G is a non-classical class-I HLA molecule associated with anti-inflammatory and immuno-modulatory properties which interacts with inhibitory receptors (ILT2/ILT4/KIR2DL4) present on various immune cells. It inhibits proliferation of B cells, T cells and natural killer cells; and also induces regulatory T cells. Recombinant human HLA-G, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Alternative Names :

HLA class I histocompatibility antigen, alpha chain G, MHC-G

Concentration :

0.25mg/ml (determined by absorbance at 280nm)

Formulation :

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol

Storage :

Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

General References :

Poomarimuthu M., et al. (2017) Pediatr Rheumatol Online J. 15(1):10.;; Sanders SK., et al. (1991) J Exp Med. 174(3):737-40.

Purity :

> 90% by SDS-PAGE

Applications :

SDS-PAGE

Antigen Species :

Human

Gene Category :

Immunology

Molecular Weight :

35.3 kDa (309aa) confirmed by MALDI-TOF

Amino Acid Sequence :

GSHSM RYFSAAVSRP GRGEPRFIAM GYVDDTQFVR FDSDSACPRM EPRAPWVEQE GPEYWEEETR NTKAHAQTDR MNLQTLRGYY NQSEASSHTL QWMIGCDLGS DGRLLRGYEQ YAYDGKDYLA LNEDLRSWTA ADTAAQISKR KCEAANVAEQ RRAYLEGTCV EWLHRYLENG KEMLQRADPP KTHVTHHPVF DYEATLRCWA LGFYPAEIIL TWQRDGEDQT QDVELVETRP AGDGTFQKWA AVVVPSGEEQ RYTCHVQHEG LPEPLMLRWK QSSLPTIPI

Tag :

His-Tag

Expression System :

E.coli

Product Type Name :

Recombinant Protein

UniProt No. :

P17693

Internal Search Terms :

HLA-G,ATGP3743-10ug,ATGP3743-20ug,ATGP3743-50ug,ATGP3743-100ug,ATGP3743-250ug,ATGP3743-500ug,ATGP3743-1mg,ATGP3743-10,ATGP3743-20,ATGP3743-50,ATGP3743-100,ATGP3743-250,ATGP3743-500,ATGP3743-1

more info or order :

NKMAX product webpage